Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Protamine: A powerfulin vivo inhibitor of bone resorption (1984)
    Springer
    Calcified tissue international 36 (1984), S. 189-193 
    Details
    ISSN: 1432-0827
    Keywords: Protamine ; Hypocalcemia ; Parathyroid hormone ; Bone resorption ; Bone turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Protamine is shown to be a powerful disrupter of calcium homeostasis, acutely inducing a severe hypocalcemia in both rabbits and rats. The magnitude of its effect correlates with bone turnover. Protamine does not significantly alter the renal excretion of calcium, and is effective whether or not there is calcium present in the gut. Protamine causes a significant fall in the specific activity of45Ca in the blood in animals whose bone has been prelabeled with45Ca. These data suggest that protamine induces hypocalcemia by blocking calcium efflux from bone. Further work seems indicated to define the biochemical mechanism of this action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405316
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Long-term remission of Crohn's disease treated with thalidomide: A seminal case report (1999)
    Springer
    Angiogenesis 3 (1999), S. 201-204 
    Details
    ISSN: 1573-7209
    Keywords: angiogenesis ; angiogenesis inhibitor ; Crohn's disease ; thalidomide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 31-year-old female with severe Crohn's disease for 15 years who had been treated with corticosteroids and 6-mercaptopurine, was treated with thalidomide initially for erythema nodosum. While on thalidomide all symptoms of Crohn's disease disappeared and she was able to discontinue all other drugs. At this writing she has been on thalidomide as sole therapy for over 4 years with the exception of a 5-week hiatus, during which time her symptoms recurred, but again disappeared after resumption of thalidomide therapy. This case suggests that thalidomide may be a useful therapy for Crohn's disease and provides impetus for a clinical trial of thalidomide for Crohn's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009027315912
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...