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  • Bone tumour  (1)
  • PACS: 42.65.Re; 42.65.Vh; 42.81.Wg  (1)
  • mitoxantrone  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Self-stabilizing additive-pulse mode-locking due to thermo-optical non-linearity in an optical fiber (1998)
    Springer
    Applied physics 66 (1998), S. 271-276 
    Details
    ISSN: 1432-0649
    Keywords: PACS: 42.65.Re; 42.65.Vh; 42.81.Wg
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: 16 , 1671 (1991)] described a Nd:YLF APM laser which somehow automatically adjusted the relative resonator phase. We reproduce this behavior and analyse its origin. Thermal effects due to the light power guided in the fiber affect the effective fiber length, which in turn influences the phase and thus the power level; hence a closed servo loop results. We demonstrate this explanation to be correct in quantitative terms. Consequences arise for other systems involving fiber-optic loops or interferometers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003400050388
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chondroblastoma: A clinical and radiological study of 104 cases (1985)
    Springer
    Skeletal radiology 14 (1985), S. 1-9 
    Details
    ISSN: 1432-2161
    Keywords: Bone tumour ; Chondroblastoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and radiographic findings in 104 patients with chondroblastoma are presented. Pain was an almost constant presenting complaint, often accompanied in the case of para-articular lesions by impaired function of an adjacent joint. The majority (80%) were in long bones with a mean age of presentation of 16 years. The characteristic radiological image of these lesions was an eccentric radiolucency, having a sharply defined sclerotic margin and containing areas of calcification in approximately a third of cases. They were always related to a growth plate. Nearly half were confined to the affected epiphysis or apophysis itself, but most of the remainder had traversed the growth plate to involve also the adjacent metaphysis. The bones around the knee and the proximal ends of the humerus and femur were the sites of predilection. A minority (20%) affected flat bones and short tubular bones of the hand and foot, with a peculiar affinity for the calcaneus and talus. The mean age of presentation of these was 28 years. The radiological pattern was similar, except for a greater tendency to expand the affected bone. Complications included the formation of a secondary aneurysmal bone cyst in 16 cases (10 of them in long bones), one malignant chondroblastoma, and one fibrosarcoma developing after radiation of the original chondroblastoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361187
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mitoxantrone, vincristine, and 5-fluorouracil with leucovorin modulation as induction chemotherapy prior to high-dose intensification in metastatic breast cancer (1993)
    Springer
    Breast cancer research and treatment 28 (1993), S. 291-294 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; induction chemotherapy ; mitoxantrone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We treated 39 women with newly diagnosed stage IV breast cancer with a new regimen of mitoxantrone 18 mg/m2 on days 1, 29, 57, vincristine 1.4 mg/m2 (maximum 2.0 mg) on days 1, 8, 15, 22, 29, 36, 43, 50, and 5-fluorouracil 375 mg/m2 on days 15–20, 43–47, 71–75 with leucovorin modulation 500 mg/m2 before each 5FU infusion (MVF). This regimen was utilized as an initial cytoreductive or induction program for these patients prior to high-dose intensification with autologous stem cell rescue. Ten patients (25%) obtained a clinical complete response and six patients (15%) obtained a partial response for an overall response rate of 40%. In addition, 10 patients had evaluable disease that was improved or stable (primarily bone and/or bone marrow metastases) after MVF induction. Thus, 26 patients (65%) were eligible for high-dose intensification with autologous stem cell rescue after MVF induction. Toxicity was primarily a mild mucositis and more commonly peripheral neuropathy. MVF therapy is an active treatment program for metastatic breast cancer but the neurotoxicity makes it difficult to recommend for widespread use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00666591
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    Paper (German National Licenses)
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