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  • Boundary concentration  (1)
  • Key words Non-small-cell lung cancer  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A phase II trial of DA-125, a novel anthracycline, in advanced non-small-cell lung cancer (1999)
    Springer
    Cancer chemotherapy and pharmacology 44 (1999), S. 518-521 
    Details
    ISSN: 1432-0843
    Keywords: Key words Non-small-cell lung cancer ; Chemotherapy ; DA-125 ; Phase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: DA-125 is a novel anthracycline derivative developed by Dong-A Pharmaceutical Company, Korea. Preclinical studies have suggested that DA-125 has greater efficacy and less toxicity than doxorubicin. The maximum tolerable dose has been shown to be 100 mg/m2 in a phase I trial. The purpose of this phase II study was to evaluate the efficacy and toxicity of DA-125 in patients with non-small-cell lung cancer (NSCLC). Methods: Chemotherapy-naive patients with histologically confirmed measurable NSCLC which was not curable by surgery or radiation therapy because of metastasis, local invasion, or recurrence were eligible for this trial. Between May 1996 and April 1997, 20 patients entered into this trial and were treated with DA-125 administered as a 5-min intravenous infusion every 3 weeks. The dose of DA-125 was 80 mg/m2 during the first cycle, and was adjusted to between 60 and 100 mg/m2 according to the observed toxicities during subsequent cycles. Results: Among 19 evaluable patients, there was no objective response to DA-125. Anemia, leukopenia and granulocytopenia of grade 3 or over were observed in 4%, 6% and 12% of chemotherapy cycles, respectively. There were no treatment-related deaths. With regard to nonhematologic toxicities, diarrhea, infection and elevated serum alkaline phosphatase of grade 3 or over were observed in 2% of cycles, but were tolerable and reversible. Conclusion: DA-125 at these doses and in this schedule was highly tolerable, but was not active in patients with advanced NSCLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800051127
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  • 2
    Electronic Resource
    Electronic Resource
    Monodisperse micron-sized cross-linked polystyrene particles. VI. Understanding of nucleated particle formation and particle growth (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 591-594 
    Details
    ISSN: 1435-1536
    Keywords: Key words Nucleated particle formation ; Urethane acrylate ; Turbidity measurement ; Boundary concentration ; Stage of particle growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  The procedure of nucleated particle formation and particle growth in dispersion polymerization was studied with the intention of understanding the production of monodisperse polystyrene particles cross-linked with urethane acrylate (UA). The time required for the formation of primary particles was determined exactly from the turbidity measurement of the reaction mixture with the polymerization time. It could be found that differing from conventional divinyl cross-linkers, such as divinylbenzene, UA had a boundary concentration where the association and coagulation of preformed nuclei with other oligomers and/or nuclei effectively took place until the primary particle formed. Similarly to linear polystyrene particles, the particle number density of the primary particles cross-linked with UA remained constant to the final particles. This observation verifies the suggestion that the primary particles cross-linked with UA readily absorbed the monomers from the medium during the stage of particle growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050561
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    Paper (German National Licenses)
    Fulltext
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