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  • 1
    Electronic Resource
    Electronic Resource
    Specificity in the genetic code: the role of nucleotide base-amino acid interaction (1971)
    New York : Wiley-Blackwell
    Biopolymers 10 (1971), S. 2083-2094 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mechanism of the unique and specific association of a given amino acid to its t-RNA is investigated by theoretical methods. Several possible schemes are proposed to explain specificity. The physical forces which act within these mechanisms are illustrated by the computer simulation of probable interactions between glycine and nucleotide bases and base pairs. It is demonstrated that glycine has direct and selective affinities for the nucleotide bases and that these interactions are principally determined by the polar groups. Energies have been calculated for the interaction of glycine with several base pairs. From these, the possibility that specificity arises through direct complexing of an amino acid with its anticodon is evaluated.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360101106
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dipeptide backbone conformation and antibody recognition of a viral octapeptide epitope (1992)
    New York : Wiley-Blackwell
    Biopolymers 32 (1992), S. 1407-1415 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The peptide YKGTMDSG (Tyr-Lys-Gly-Thr-Met-Asp-Ser-Gly) represents an important antigenic determinant from the glycoprotein G2 of the pathogenic Rift Valley fever virus. By preparing a series of single-residue substitution peptides, the importance to antigenicity of individual residues within this octapeptide has been determined. Here, we investigated a simple and rapid computational analysis to test for correlations between the observed antigenicity of the substitution analogue peptides and the calculated conformational preferences in local regions of the peptides. Conformational energy analyses were carried out on all dipeptide combinations represented in the wild-type octapeptide and in the singleresidue substitution analogue peptides. Conformational similarities and differences between wild-type and substitution dipeptide pairs were determined. The results of these computational analyses were then compared with the data on the relative antigenicity of the wild-type octapeptide and the substitution analogues. This comparison revealed a positive correlation. Substitution peptides showing changes in antigenicity possessed significant changes in the calculated backbone conformation relative to wild type in the dipeptides encompassing the residue substitution. Substitution peptides showing no change in antigenicity similarly showed no significant changes in dipeptide conformation. The potential utility of dipeptide conformational energy analyses and this preliminary structure-activity correlation are discussed. © 1992 John Wiley & Sons, Inc.
    Additional Material: 8 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360321013
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of lipoproteins on macrophage superoxide generation (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 13 (1995), S. 135-140 
    Details
    ISSN: 0263-6484
    Keywords: Macrophage ; lipoproteins ; superoxide ; free radicals ; oxidation ; atherosclerosis ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Superoxide production by macrophages and leukocytes may have an important role in atherogenesis. Whether lipoproteins modulate the superoxide production of these cells is not clear. Therefore, the effect of lipoproteins on the production of superoxide by rat peritoneal macrophages was tested. VLDL and LDL inhibited digitonin-stimulated superoxide production in a dose-dependent manner. Maximum inhibition was observed at 10 μg ml-1 of VLDL protein and 50 μg ml-1 of LDL protein respectively. In contrast, HDL (40 μg protein ml-1) enhanced digitoninstimulated superoxide production (by 47 per cent). Macrophage superoxide production induced by arachidonic acid was enhanced by both VLDL (130 per cent) and HDL (84 per cent), whereas LDL had no effect. The lipoproteins had no effect on macrophage superoxide stimulated by other agonists such as phorbol myristate 13-acetate, sodium fluoride or the calcium ionophore, A23187. The effect of lipoproteins was also tested on human polymorphonuclear leukocyte superoxide generation, stimulated by digitonin and PMA. Ten μg of VLDL, 50 μg of LDL and 50 μg of HDL proteins ml-1, inhibited digitonin-induced superoxide production by 50, 100 and 33 per cent respectively. Lipoproteins had no effect on PMA stimulated superoxide generation by human polymorphonuclear leukocytes. The stimulatory and inhibitory effects of lipoproteins on macrophage and neutrophil superoxide generation could be important in the understanding of oxidation-mediated development of atherosclerosis.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290130210
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Dynamic simulation of the hydrodynamic interaction among immersed particles in Stokes flow (1990)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 10 (1990), S. 791-809 
    Details
    ISSN: 0271-2091
    Keywords: Stokes flow ; Hydrodynamic interactions ; Suspension flows ; Two-phase ; flows ; Boundary element method ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A numerical method for the dynamic simulation of the hydrodynamic interaction among particles in Stokes flow is developed. The method couples the quasi-static Stokes equations for the fluid with the equilibrium equations for the particles. The boundary element method is used to represent the velocity at a general field point in terms of surface velocities and stresses. However, neither the stresses nor the velocities are assumed to be known on the surface of the particles. Kinematic equations relating the linear and angular velocities at the centroids of the particles to the surface velocities are combined with the discretized boundary element equations and the equilibrium equations to generate a system of linear equations. The associated coefficient matrix is correspondent to the grand resistance matrix which relates the velocities of the particles to a given geometry.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650100706
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Numerical modelling of cavities on axisymmetric bodies at zero and non-zero angle of attack (1992)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 15 (1992), S. 251-271 
    Details
    ISSN: 0271-2091
    Keywords: Cavitation flow ; Cavity closure model ; Drag on cavitating bodies ; Boundary element method ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The flow about submerged, fully cavitating axisymmetric bodies at both zero and non-zero angle of attack is considered in this paper. A cavity closure model that relates the point of detachment, the angle that the separating streamline makes with the body and the cavity length is described. The direct boundary element method is used to solve the potential flow problem and to determine the cavity shape. A momentum integral boundary layer solver is included in the formulation so that shear stresses can be incorporated into the drag calculations. The numerical predictions based on the proposed closure model are compared with water tunnel measurements and photographs.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650150302
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Numerical simulation of the hydrodynamic interaction between a sedimenting particle and a neutrally buoyant particle (1989)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 9 (1989), S. 263-273 
    Details
    ISSN: 0271-2091
    Keywords: Low-Reynolds-number flow ; Sedimentation ; Hydrodynamic interactions ; Two-phase flows ; Suspensions ; Boundary element method ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A new method for the simulation of the translational and rotational motions of a system containing a sedimenting particle interacting with a neutrally buoyant particle has been developed. The method is based on coupling the quasi-static Stokes equations for the fluid with the rigid body equations of motion for the particles. The Stokes equations are solved at each time step with the boundary element method. The stresses are then integrated over the surface of each particle to determine the resultant forces and moments. These forces and moments are inserted into the rigid body equations of motion to determine the translational and rotational motions of the particles. Unlike many other simulation techniques, no restrictions are placed on the shape of the particles. Superparametric boundary elements are employed to achieve accurate geometric representations of the particles. The simulation method is able to predict the local fluid velocity, resolve the forces and moments exerted on the particles, and track the particle trajectories and orientations.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650090303
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    Paper (German National Licenses)
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