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Crohn's disease: the Melbourne experience (1992)

McLain, B. I. ; Davidson, P. M. ; Beasley, S. W. ; [et al.]

Springer

Pediatric surgery international 7 (1992), S. 165-170

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ISSN: 1437-9813

Keywords: Crohn's disease ; Childhood ; Bowel resection

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract During the years 1979–1988, 63 children (38 male: 25 female) were first diagnosed as having Crohn's disease on the basis of histological findings. Twenty-nine per cent were less than 10 years old at the onset of symptoms; 40% of these cases took more than 1 year to diagnose. Most patients (59%) presented with abdominal pain and diarrhoea, but 40% presented with: a non-specific illness (14%); upper gastro-intestinal tract symptoms (14%); growth failure (6%); systemic disease (5%), or peri-anal disease (1%). There were signs of abdominal tenderness, distension, or an abdominal mass in over 50% of cases. Peri-anal Crohn's disease was present in 41% and a height less than the 10th centile was recorded at diagnosis in 45%. Children were treated with a combination of prednisolone and sulphasalazine. In 16 cases a bowel resection was performed. Surgery was indicated for localised stricture formation causing obstruction and for persistence of severe disease poorly responsive to steroids, particularly in the prepubertal child with growth failure. The extent and distribution of disease influenced outcome. Twenty-four of 39 children followed for more than 3 years are either well-controlled or disease-free at present.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00175830

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Ion channels in boar sperm plasma membranes: Characterization of a cation selective channel (1991)

Cox, Thomas ; Campbell, P. ; Peterson, R. N.

New York, NY [u.a.] : Wiley-Blackwell

Molecular Reproduction and Development 30 (1991), S. 135-147

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ISSN: 1040-452X

Keywords: Calcium channels ; Ruthenium red ; Verapamil ; Nitrendipine ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: Plasma membranes isolated from cauda epididymal and ejaculated boar sperm were inserted into planar lipid bilayers and examined for the presence of ion channels. Channel fusion was frequently observed; the most prominent was a nonselective cation channel which conducted K, Na, Cs, Ca, and Ba. Channel opening did not show a strict dependence on voltage but was partially blocked by verapamil, nitrendipine, and ruthenium red. A channel with these characteristics was observed when plasma membranes were isolated by high-pressure nitrogen cavitation (650 psi, 78% sperm head plasma membranes) or at very low nitrogen pressures (50 psi, 90% sperm head plasma membranes), suggesting that this channel may be present in the plasma membrane overlying the sperm head.

Additional Material: 10 Ill.