ISSN:
1619-7089
Keywords:
Technetium-99m
;
Single-photon emission tomography
;
Basal ganglia
;
Brain
;
Parkinson's syndrome
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Technetium-99m TRODAT-1, a tropane derivative, has shown promise as a tracer for the imaging of dopamine transporters in preliminary studies in rats and baboons. The present report concerns the first study of the use of [99mTc]TRODAT 1 for the same purpose in humans. The specific uptake of [99mTc]TRODAT1 in dopamine transporter sites located in the basal ganglia area was confirmed: the best contrast between the basal ganglia and the occipital area, which is devoid of dopamine transporters, was achieved at 120–140 min following injection. The development of a99mTc-based agent bypasses the need for cyclotron-produced radionuclides, which will be of benefit for routine clinical studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01254479
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