ISSN:
1432-1912
Keywords:
Aromatic Amino Acid Decarboxylase
;
Biosynthesis of Brain Monoamines
;
Brain Monoamine Neurons
;
Dopa
;
5-Hydroxytryptophan
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The investigation was carried out in order to establish the origin of 5-hydroxytryptophan (5-HTP) accumulating in the brain following treatment with he decarboxylase inhibitor Ro 4-4602 [N-(DL seryl)-N1-(2,3,4-trihydroxybenzyl) hydrazine]. In biochemical studies the distribution of 5-HTP in the brain of rats treated with Ro 4-4602 was similar to the normal distribution of 5-hydroxytryptamine (5-HT). In contrast the 5-HTP accumulating after i.p. injection of this compound was evenly distributed in different parts of the brain. In histochemical studies performed on reserpine-treated rats specific fluorescence, apparently derived from accumulating 5-HTP and dopa, could be demonstrated in 5-HT- and dopamine-carrying nerve cell bodies and terminals following treatment with Ro 4-4602. Taken together, the available biochemical and histochemical studies indicate that the 5-hydroxytryptophan and dopa accumulating in the brain following decarboxylase inhibition are mainly or entirely formed by the aromatic amino acid hydroxylases of central 5-HT- and catecholamine-carrying neurons, respectively.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01422011
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