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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Internist 38 (1997), S. 917-923 
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Leberszintigraphie ; Lebertumor ; Lebermetastasen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Die nuklearmedizinische Diagnostik der Leber beruht im wesentlichen auf 3 Anreicherungsmechanismen: •*Speicherfähigkeit der von Kupfferschen Sternzellen des retikuloendothelialen Systems für Kolloide, •*Aufnahme, Umbau und Exkretion von Iminodiazetatverbindungen durch Hepatozyten, •*Darstellbarkeit des Blutpools mit markierten Erythrozyten Die verschiedenen szintigraphischen Methoden, die bei der Leberdiagnostik zur Anwendung kommen, werden mit ihren Indikationsstellungen hier eingehend dargestellt. Nuklearmedizinische ergänzen die morphologischen Methoden und tragen zur Differentialdiagnostik von Raumforderungen in der Leber bei. Sie liefern zugleich wichtige Informationen zur Leberfunktion.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Radiologe 40 (2000), S. 916-924 
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Leber ; Szintigraphie ; Lebertumor ; Keywords Liver ; Scintigraphy ; Focal liver disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Four types of radionuclide investigations are described here: 99mTc-labeled red blood cell scintigraphy, colloid liver scintigraphy, hepatobiliary scintigraphy, and positron emission tomography with [18F]fluorodeoxyglucose. The role of nuclear imaging techniques in the diagnosis of liver diseases has changed in recent years and now compliments morphological imaging modalities by offering the unique ability to visualize function and metabolism. The studies described here are therefore rarely performed now by themselves for the delineation of secondary liver tumors. These radionuclide investigations are used principally to narrow the differential diagnosis of focal liver disease.
    Notes: Zusammenfassung Vier verschiedene nuklearmedizinische Untersuchungsverfahren werden vorgestellt: die Blutpool- und Perfusionsszintigraphie, die Kolloidszintigraphie, die hepatobiliäre Funktionsszintigraphie und die Positronenemissionstomographie mit 18F-FDG. In der Diagnostik von Lebererkrankungen hat sich die Rolle der Nuklearmedizin gewandelt. Nuklearmedizinische Techniken ergänzen die morphologisch orientierten bildgebenden Verfahren durch die einzigartige Möglichkeit der Darstellung von Funktion und Metabolismus. Daher wird die Szintigraphie kaum noch zur Abbildung von sekundären Lebertumoren durchgeführt. Die beschriebenen nuklearmedizinischen Methoden finden ihren Einsatz vorwiegend in der differenzialdiagnostischen Eingrenzung fokaler Leberläsionen.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 14 (1988), S. 446-452 
    ISSN: 1619-7089
    Keywords: Brain death ; Cerebral blood flow ; Pediatric intensive care ; Organ donation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Determination of brain death in infants and children is difficult and criteria used in adult brain death are regarded insufficient in pediatric cases. In comatose children, clinical signs of brain death and EEG monitoring may be of limited value, while intercerebral blood flow estimations can provide more direct information. Beside radionuclide bolus angiography of polar radiopharmaceuticals with sequential technique, two radioisotopes are introduced for static brain images. Injection of 123I-amphetamine or the 99mTc labelled lipophilic complex HM-PAO into the peripheral venous circulation enables more precise static imaging of parenchymatous brain perfusion and cellular function in contrast to conventional dynamic imaging because of retention in the intact brain parenchyma. Critical deficits or complete loss of cerebral perfusion can be readily documented. These studies are particularly helpful when clinical signs and EEG alone cannot establish the definite diagnosis of brain death. Their easy application and wide availability renders them especially useful in children.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 24 (1997), S. 635-641 
    ISSN: 1619-7089
    Keywords: Key words: Liver cirrhosis ; Portal hypertension ; Transjugular intrahepatic portosystemic shunt ; Liver perfusion scintigraphy ; Liver blood flow ; TIPS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. In patients with liver cirrhosis a transjugularly placed intrahepatic portocaval shunt (TIPS) is a non-surgical portosystemic device which aims to reduce portal venous pressure. In comparison with Doppler sonography, we evaluated in 28 patients the diagnostic impact of liver perfusion scintigraphy (with technetium-99m diethylene triamine penta-acetic acid) in the assessment of changes in the hepatic blood flow after TIPS shunting. The arterial and portal contributions to hepatic flow were calculated from the areas under the biphasic time-activity curve. In the course of TIPS shunting, patency is threatened by reocclusion. Angiography is the gold standard for TIPS shunt reassessment. However, there is a need for a less invasive diagnostic procedure, such as scintigraphy or Doppler sonography, for the early detection of shunt insufficiency. Scintigraphy demonstrated that prior to TIPS shunting the portal venous contribution to hepatic perfusion was reduced to 29.2%, this reduction being due to portal hypertension. After TIPS placement a significant increase in portal venous perfusion was observed (38.2%; P〈0.02). TIPS shunt occlusion was identified in patients by a significant reduction in the scintigraphically measured portal venous contribution to hepatic blood flow. Hepatic perfusion scintigraphy appears to be a valuable method to determine the immediate effect of TIPS on hepatic blood flow. Post-TIPS follow-up studies of hepatic haemodynamics by liver perfusion scintigraphy appear able to contribute to the detection of TIPS shunt occlusion before the clinical consequences of this complication have become apparent.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 24 (1997), S. 635-641 
    ISSN: 1619-7089
    Keywords: Liver cirrhosis ; Portal hypertension ; Transjugular intrahepatic portosystemic shunt ; Liver perfusion scintigraphy ; Liver blood flow ; TIPS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In patients with liver cirrhosis a transjugularly placed intrahepatic portocaval shunt (TIPS) is a non-surgical portosystemic device which aims to reduce portal venons pressure. In comparison with Doppler sonography, we evaluated in 28 patients the diagnostic impact of liver perfusion scintigraphy (with technetium-99m diethylene triamine penta-acetic acid) in the assessment of changes in the hepatic blood flow after TIPS shunting. The arterial and portal contributions to hepatic flow were calculated from the areas under the biphasic timeactivity curve. In the course of TIPS shunting, patency is threatened by reocclusion. Angiography is the gold standard for TIPS shunt reassessment. However, there is a need for a less invasive diagnostic procedure, such as scintigraphy or Doppler sonography, for the early detection of shunt insufficiency. Scintigraphy demonstrated that prior to TIPS shunting the portal venons contribution to hepatic perfusion was reduced to 29.2%, this reduction being due to portal hypertension. After TIPS placement a significant increase in portal venous perfusion was observed (38.2%;P〈0.02). TIPS shunt occlusion was identified in patients by a significant reduction in the scintigraphically measured portal venons contribution to hepatic blood flow. Hepatic perfusion scintigraphy appears to be a valuable method to determine the immediate effect of TIPS on hepatic blood flow. Post-TIPS follow-up studies of hepatic haemodynamics by liver perfusion scintigraphy appear able to contribute to the detection of TIPS shunt occlusion before the clinical consequences of this complication have become apparent.
    Type of Medium: Electronic Resource
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