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  • 1
    Electronic Resource
    Electronic Resource
    Pathology of human malignant gliomas after radiation and chemotherapy (1980)
    Springer
    Acta neurochirurgica 53 (1980), S. 205-216 
    Details
    ISSN: 0942-0940
    Keywords: Malignant gliomas ; pathology ; radio ; chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pathological effects of radio- and chemotherapy have been studied in 31 malignant gliomas. The brains have been examined by means of the complete study technique. Many histological features have been related to surgery, localization, preoperative duration, postoperative survival, irradiation, and chemotherapy. No specific alterations have been found, but some positive correlations have been established: decrease of mitoses, occurrence of macrophages and vessel degeneration after radiation, increase of monstrous cells after chemotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02074793
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chemotherapy for malignant gliomas of the brain: a review of ten-years experience (1990)
    Springer
    Acta neurochirurgica 103 (1990), S. 35-46 
    Details
    ISSN: 0942-0940
    Keywords: Brain neoplasm ; chemotherapy ; malignant glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In recent years, there has been a great improvement in the knowledge of the biological aspects of malignant gliomas of the brain. Conversely, there has been an increase of interest in the multimodal treatment of these tumours. In this review, we have analyzed the results of the several reports which have appeared in the literature that deal with the chemotherapeutic treatment of malignant gliomas. Furthermore, some areas of biological investigation that could have an impact on pharmacological therapy are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420190
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Radio- and chemotherapy of malignant gliomas. Pathological changes in the normal nervous tissue (1981)
    Springer
    Acta neurochirurgica 58 (1981), S. 37-58 
    Details
    ISSN: 0942-0940
    Keywords: Malignant gliomas ; radiotherapy ; chemotherapy ; cerebral radionecrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pathological effects of radio- and chemotherapy on the normal nervous tissue have been studied in 42 brains with malignant gliomas. The brains have been examined by means of the complete study technique. In seven cases the picture of delayed radionecrosis has been found. Apart from this, many histological features have been related to post-operative survival, radiation dose, interval between radiation and death, chemotherapy, steroids, size and activity of the tumour. Some alterations, such as peritumoural necroses, macrophage areas, vessel wall degenerations etc. result from radiotherapy. The relations and pathogenesis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401682
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Radio-chemo-immunotherapy (CCNU plus Levamisole) for treatment of metastatic brain tumors (1984)
    Springer
    Journal of neuro-oncology 2 (1984), S. 237-240 
    Details
    ISSN: 1573-7373
    Keywords: brain metastasis ; CCNU ; radiotherapy ; Levamisole
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-one patients with metastatic brain tumors were treated with Radiotherapy (RT) and CCNU or with RT, CCNU and Levamisole (LMS) in a randomized clinical trial. Twenty-seven were evaluable. All patients were submitted to whole brain radiation (50 ± 5 Gy) and CCNU (130 mg/ m2 p. o. every 8 weeks). 15 also received Levamisole (2.5 mg/ kg p.o. daily for 3 weeks in the first month, for 2 weeks in the second, and then once a week monthly until progression). Primary tumor was predominantly lung cancer (22/27) and brain lesions were generally multiple (24/27). The overall response rate was 35% in the RT plus CCNU treated group and 38% in the RT plus CCNU plus LMS treated group. The median survival time was similar and not statistically different in both groups (7 versus 6 months). No important side effects were observed either in the RT + CCNU or in the RT + CCNU + LMS treated groups. The absence of combined depression of T-cell levels and responsiveness of lymphocytes to mitogens suggests that thymus dependent immunity could be improved by LMS administration. However, such improvement had no impact on duration of survival in patients with metastatic brain tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253275
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    Paper (German National Licenses)
    Fulltext
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