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  • Epilepsy  (2)
  • Brain neoplasm  (1)
  • Encephalitis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Intracranial and spinal metastases from a ganglioglioma with unusual cytogenetic abnormalities in a patient with complex partial seizures (1997)
    Springer
    Child's nervous system 13 (1997), S. 550-555 
    Details
    ISSN: 1433-0350
    Keywords: Key words Ganglioglioma ; Cytogenetics ; Metastasis ; Brain neoplasm ; Pathology ; Epilepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe an unusual clinical presentation of a ganglioglioma in a patient with complex partial seizures. The patient underwent a right temporal lobectomy with subtotal tumor resection at age 15 years, followed by a complete resection 1 year later. Follow-up MRI scan a year later documented recurrence and leptomeningeal dissemination. Another biopsy was performed. Pathological examination revealed similar histology in all three resections, with a ganglioglioma showing no evidence of anaplasia. The tumor exhibited a number of karyotypic abnormalities, notably, a paracentric inversion of chromosome 7. In summary, despite lacking anaplastic features by conventional histological criteria, this ganglioglioma showed an unsusual karyotype and demonstrated radiological evidence of widespread dissemination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050136
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  • 2
    Electronic Resource
    Electronic Resource
    Coexistence of hemimegalencephaly and chronic encephalitis Detection of cytomegalovirus by the polymerase chain reaction (1997)
    Springer
    Child's nervous system 13 (1997), S. 35-41 
    Details
    ISSN: 1433-0350
    Keywords: Key words Cytomegalovirus ; Hemimegalencephaly ; Encephalitis ; Epilepsy ; Brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the extraordinary association of hemimegalencephaly with chronic encephalitis and cytomegalovirus (CMV) positivity in a 5-month-old infant with intractable seizures and a left hemisphere resection. Microscopy revealed a severe neuronal migration disorder (NMD) with fusion of gyri, marked disarray of neuronal lamination, neuronal gigantism and extensive neuronal heterotopias. Also widespread were microglial nodules, gliosis and nodular calcifications and some foci of frank necrosis with calcification. Occasional perivascular and leptomentingeal lymphocytic infiltrates were present. No viral inclusions were identifiable. Polymerase chain reaction on multiple specimens showed unequivocal CMV positivity. In intrauterine CMV infection, NMDs such as polymicrogyria are well recognized, but the association of hemimegalencephaly with CMV infection has not previously been described. Our finding of chronic encephalitis with CMV positivity and hemimegalencephaly in the same patient raises questions about the role of CMV in the etiopathogenesis of the NMD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810050037
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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