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  • 1
    Electronic Resource
    Electronic Resource
    Metastasis of renal carcinoma colliding with glioblastoma (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 448-452 
    Details
    ISSN: 1432-0533
    Keywords: Collision tumors ; Metastasis of cancer to cancer ; Glial fibrillary acidic protein ; Cytokeratins ; Brain tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report presents the case of a 74-year-old woman who was simultaneously affected by two highly malignant neoplasms, a metastasizing renal cell carcinoma and a glioblastoma with sarcomatous component. Leptomeningeal metastasis of renal carcinoma is shown to invade the glioblastoma at its margin. Especially in gliomas, “cancer to cancer” phenomenoma are only rarely documented. Support by immunohistochemical data may prove those events to be more frequent than assumed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307701
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mitoxantrone-induced DNA strand breaks in cell-cultures of malignant human astrocytoma and glioblastoma tumors (1997)
    Springer
    Journal of neuro-oncology 32 (1997), S. 203-208 
    Details
    ISSN: 1573-7373
    Keywords: mitoxantrone ; malignant human brain tumors ; DNA strand breaks ; alkaline elution ; flourescence spectrophotometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study mitoxantrone (Mtx) induced DNA strand breaks were measured with the alkaline elution technique in short term cell cultures derived from human gliomas. Glioblastomas or astrocytomasfrom 5 patients who underwent intracranial surgery were cultured and incubated 1 h with different concentrations of Mtx (0, 0.01, 0.1 and 1.0 μg/ml). The alkaline elution methodwas modified to measure DNA lesions in human gliomas. Mtx inducedDNA strand breaks in a dose dependent manner in all cell culturestested. There was a linear increase of DNA strand break frequencyinduced by Mtx between 0.01—1.0 μg/ml. Concerning these in vitro data, Mtx might be potentially useful for the treatment ofpatients with malignant brain tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005792410604
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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