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  • Brainstem auditory evoked response  (1)
  • Child  (1)
  • 1
    ISSN: 1432-2072
    Keywords: 5-Hydroxytryptophan ; Imipramine ; Brainstem auditory evoked response ; Middle latency auditory evoked response ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The neurophysiological effects of acute and chronic treatment with the tricyclic antidepressant drug imipramine were investigated. Brainstem (BAER) and middle latency (MLR) auditory evoked responses were monitored in the alert and immobile rat. Daily injection of imipramine (10 mg/kg, IP) for 2 weeks produced a 13% increase in the latency and a 35% reduction in the amplitude of the N17 component of the MLR. Acute imipramine treatment had no effect. There was no observable change in the BAER after either acute or chronic drug administration. Serotonergic function was assessed by studying the inhibitory effects of 5-hydroxytryptophan on the BAER and MLR. Chronic application of imipramine caused an apparent reduction of the effects of 5-hydroxytryptophan (75 mg/kg, IP) on the N17 component of the MLR. This may, however, be due to the shift in baseline latency and amplitude. Inhibition of the BAER by 5-hydroxytryptophan was unaltered by long term exposure to imipramine. Acute treatment with imipramine was without effect on the modulation of the BAER and the MLR by 5-hydroxytryptophan. These results provide evidence that chronic, as opposed to acute, administration of imipramine had an inhibitory effect on auditory processing at the level of the MLR and that this may be associated with a change in the net output of the serotonergic system.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-5195
    Keywords: Child ; Foot ; Mobile flat foot
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les résultats d'une étude clinique et radiologique de pieds plats réductibles chez l'enfant sont présentés. Dans cette série, 50 enfants suivis pendant 4 ans ont été traités en combinant de façon variée les chaussures, les semelles orthopédiques et les contreforts. Les auteurs concluent que l'enfant présentant un pied plat réductible sera bien soutenu au début par le port de bottines lacées, armées d'une empeigne en acier et de contrefort solide. Un contrefort scaphoïdien fait sur mesure doit être ajouté, si le tableau douloureux n'est pas amendé par les souliers préconisés. Les pelotes scaphoïdiennes paraissent être inefficaces.
    Notes: Summary A clinical and radiological study in 50 children with symptomatic mobile flat feet treated with varying combinations of shoes, custom-made arch supports, and pads over a period of four years is presented. It was concluded that children with symptomatic mobile flat feet should be fitted initially with laced high top shoes containing a steel shank and firm counter. A custom-made navicular pad should be added if adequate symptomatic relief is not obtained from the recommended shoes. Navicular cookies were found to be ineffective.
    Type of Medium: Electronic Resource
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