Electronic Resource
Springer
Archives of toxicology
43 (1980), S. 257-262
ISSN:
1432-0738
Keywords:
Bromobenzene
;
Cytochrome P-450
;
Cytochrome reductase
;
Glucuronyltransferase
;
Lipoperoxidation
;
Liver
;
Mixed-function oxidase
;
Peroxide
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract In acute oral studies, the effect of bromobenzene on hepatic microsomal enzymes was investigated. Neither glucuronyltransferases nor cytochrome c reductase showed significant changes. Most of the mixed-function oxidases studied were inhibited with the exception of ketamine-N-demethylase. The data indicate that bromobenzene or its epoxide acts on cytochrome P-450 but not on all cytochrome P-450 species, and does not affect the reductase and the glucuronyltransferases. Microsomal lipoperoxidation and microsomal H2O2 formation were increased.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00366181
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