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  • 1
    Electronic Resource
    Electronic Resource
    Effect of dopamine agonist medication on prolactin producing pituitary adenomas (1991)
    Springer
    Virchows Archiv 418 (1991), S. 439-446 
    Details
    ISSN: 1432-2307
    Keywords: Bromocriptine ; Pituitary neoplasm ; Prolactin ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Conventional light microscopy, immunocyto-chemistry, electron microscopy and in situ hybridization were used to evaluate the effect of dopamine agonists (bromocriptine-LAR and bromocriptine) on the morphology of surgically removed prolactin (PRL)-producing pituitary adenomas. Dopamine agonist therapy resulted in decrease of serum PRL, clinical improvement and tumour shrinkage. Using light and electron microscopy cellular atrophy, interstitial and perivascular fibrosis were noted; in several tumours connective tissue accumulation was pronounced. The cellular response was not uniform. In some adenomas populations of large cells and small cells were distinguished. The large cells contained immunoreactive PRL and expressed the PRL gene indicating resistance to dopamine agonists. It appears that these cells retained the potential to secrete PRL and proliferate despite exposure to dopamine agonists. In the small cells, PRL immunoreactivity and PRL gene expression decreased providing evidence that both PRL release and synthesis were blocked. Small cells can persist in tumours after discontinuation of dopamine agonist medication suggesting these small cells are irreversibly suppressed and are not capable of regaining their endocrine function and proliferative capability. The formation of irreversibly suppressed PRL cells may explain why some PRL-producing adenomas do not recur after withdrawal of dopamine agonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605931
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Thermoanalytical Investigations on Intercalated Kaolinites (1998)
    Springer
    Journal of thermal analysis and calorimetry 53 (1998), S. 467-475 
    Details
    ISSN: 1572-8943
    Keywords: cesium acetate ; intercalation ; kaolinite ; mass spectrometry ; potassium acetate ; Raman microscopy ; thermal analysis ; urea ; X-ray diffraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The thermal behaviour of ordered kaolinites from Hungary and Australia intercalated with potassium acetate, cesium acetate and urea has been investigated by simultaneous TG-DTG-DTA, TG-MS, Raman microscopy and XRD. Remarkable changes in the thermal decomposition pattern of the intercalates were obtained as a function of the nature of the intercalating re-agents. Replacing the potassium cation to cesium leads to a change in the OH environments resulting in a more complicated dehydroxylation pattern. The urea intercalates can be decomposed completely without dehydroxylating the mineral, although further treatments are necessary to restore the original d-spacing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010189324654
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Thermal Behaviour of Kaolinite Intercalated with Formamide, Dimethyl Sulphoxide and Hydrazine (1999)
    Springer
    Journal of thermal analysis and calorimetry 56 (1999), S. 885-891 
    Details
    ISSN: 1572-8943
    Keywords: evolved gas analysis ; intercalation ; kaolinite ; TG-DTG-DTA ; X-ray powder diffraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The thermal behaviour of kaolinites intercalated with formamide, dimethyl sulphoxide and hydrazine has been studied by simultaneous TG-DTG-DTA-EGA and TG-MS techniques. The complexes can be decomposed completely without dehydroxylating the mineral. It was found that the amount of intercalated guest molecules per inner surface OH-group is close to unity for the formamide and dimethyl sulphoxide intercalates. For the intercalation of hydrazine it was found that hydrazine is locked in the expanded mineral as hydrazine hydrate and its amount is somewhat higher than that obtained for the other two reagents. The thermal evolution patterns of the guest molecules revealed that all the three reagents are bonded at least in two different ways in the interlayer space.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010139113778
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    Paper (German National Licenses)
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