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  • 1
    ISSN: 1432-069X
    Keywords: Secretory component ; Interferon gamma ; ICAM-1 ; HLA-DR ; Psoriasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Secretory component (SC) acts as a transmembrane polymeric immunoglobulin receptor of epithelial cells and is known to bind to polymeric IgA and to contribute to the secretion of secretory IgA (sIgA). We describe a new biological function for free SC (FSC) by which the expression of intercellular adhesion molecule-1 (ICAM-1) and HLA-DR induced by interferon gamma (IFNγ) is inhibited in human keratinocytes. This activity coincided with suppression of adenosine cyclic 3,5-monophosphate (cyclic AMP) production in keratinocytes. Keratinocytes produced SC after stimulation with IFNγ and this production was suppressed by the addition of H-7 or propranolol. The addition of propranolol resulted in prolongation of ICAM-1 expression on keratinocytes induced by IFNγ. These results suggest that endogenously produced SC, as well as exogenously added FSC, acts as an inhibitor of IFNγ. Therefore, our results suggest that SC plays an antiinflammatory role in the pathogenesis of inflammatory skin diseases via inhibition in keratinocytes of IFNγ induced expression of ICAM-1 and HLA-DR.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 102 (1999), S. 127-146 
    ISSN: 1573-2878
    Keywords: Trust-region methods ; unconstrained optimization ; Bunch–Parlett factorization ; optimal paths ; global convergence ; local convergence rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Trust-region algorithms solve a trust-region subproblem at each iteration. Among the methods solving the subproblem, the optimal path algorithm obtains the solution to the subproblem in full-dimensional space by using the eigenvalues and eigenvectors of the system. Although the idea is attractive, the existing optimal path method seems impractical because, in addition to factorization, it requires either the calculation of the full eigensystem of a matrix or repeated factorizations of matrices at each iteration. In this paper, we propose a scaled optimal path trust-region algorithm. The algorithm finds a solution of the subproblem in full-dimensional space by just one Bunch–Parlett factorization for symmetric matrices at each iteration and by using the resulting unit lower triangular factor to scale the variables in the problem. A scaled optimal path can then be formed easily. The algorithm has good convergence properties under commonly used conditions. Computational results for small-scale and large-scale optimization problems are presented which show that the algorithm is robust and effective.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 97 (1998), S. 385-406 
    ISSN: 1573-2878
    Keywords: Unary optimization ; trust-region methods ; indefinite dogleg curve ; Bunch–Parlett factorization ; rank-one update
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract In this paper, we propose two modified partial-update algorithms for solving unconstrained unary optimization problems based on trust-region stabilization via indefinite dogleg curves. The two algorithms partially update an approximation to the Hessian matrix in each iteration by utilizing a number of times the rank-one updating of the Bunch–Parlett factorization. In contrast with the original algorithms in Ref. 1, the two algorithms not only converge globally, but possess also a locally quadratic or superlinear convergence rate. Furthermore, our numerical experiments show that the new algorithms outperform the trust-region method which uses the partial update criteria suggested in Ref. 1.
    Type of Medium: Electronic Resource
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