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  • 1
    ISSN: 1432-2072
    Keywords: Nicotine ; Bungarotoxin ; Cholinergic receptor binding ; Corticosterone ; Glucocorticoids ; Adrenalectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Glucocorticoid regulation of nicotine sensitivity was investigated in adrenalectomized (ADX) and sham-operated C3H mice administered chronic corticosterone (CCS) replacement therapy. Hormone pellets (60% CCS or pure cholesterol) were implanted at the time of surgery and animals were tested for nicotine sensitivity in a battery of behavioral and physiological tests. ADX-induced increases in nicotine sensitivity were reversed by chronic CCS replacement. Sham-operated animals that received CCS supplementation were subsensitive to the effects of nicotine. In both ADX and sham-operated animals, chronic CCS administration induced a decrease in the number of CNS nicotinic cholinergic receptors labeled by alpha-[125I]-bungarotoxin. Binding was decreased by 30–60% depending on brain region; no changes in affinity (K d ) were detected. The number of brain nicotinic sites labeled by [3H]-nicotine was unaltered following 1 week of chronic CCS administration. These data support the hypothesis that glucocorticoids modulate nicotine sensitivity in the C3H mouse. In animals chronically treated with CCS, nicotine tolerance may be due to CCS-induced changes in nicotinic cholinergic receptor binding or the presence of high CCS titers at the time of testing.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1572-9672
    Keywords: Interstellar dust ; Ulysses dust measurements ; Galileo dust measurements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Interstellar dust detected by the dust sensor onboard Ulysses was first identified after the Jupiter flyby when the spacecraft's trajectory changed dramatically (Grün et al., 1994). Here we report on two years of Ulysses post-Jupiter data covering the range of ecliptic latitudes from 0° to −54° and distances from 5.4 to 3.2 AU. We find that, over this time period, the flux of interstellar dust particles with a mean mass of 3·10−13 g stays nearly constant at about 1·10−4, m−2 s−1 (π sr)−1, with both ecliptic latitude and heliocentric distance. Also presented are 20 months of measurements from the identical dust sensor onboard the Galileo spacecraft which moved along an in-ecliptic orbit from 1.0 to 4.2 AU. From the impact direction and speeds of the measured dust particles we conclude that Galileo almost certainly sensed interstellar dust outside 2.8 AU; interstellar particles may also account for part of the flux seen between 1 and 2.8 AU.
    Type of Medium: Electronic Resource
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