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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Inflammation research 48 (1999), S. 255-261 
    ISSN: 1420-908X
    Schlagwort(e): Key words: SLE — Cytokines — B-cells — Autoantibodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Systemic lupus erythematosus (SLE) is an autoimmune disease most prevalent in women between the ages of twenty and sixty. Successful treatment remains challenging due to a lack of understanding of the underlying mechanisms and multiple symptoms ranging from skin rashes to glomerulonephritis. The pathogenesis of SLE has been linked to a B-cell hyperproliferation unique to afflicted patients. These B-cells generate large quantities of IgG autoantibodies, ultimately capable of leading to lupus nephritis and renal failure. The significance of cytokines in SLE and in murine lupus, a related disease in mice, has been debated, particularly with respect to B-cell activity. Potential roles of auto-regulatory and inflammatory cytokines have been investigated. In particular, IL-6 and IL-10 have been shown to be key factors in regulating autoantibody-secreting B-cell activity in lupus. Here, we will provide a critical overview of our current knowledge of the regulatory roles of these two cytokines in SLE.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 2891-2909 
    ISSN: 0029-5981
    Schlagwort(e): C++ ; object-oriented ; solidification ; parallel ; Engineering ; Numerical Methods and Modeling
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This paper describes an implementation in C++ and in parallel of an explicit finite element formulation for the solution of transient heat conduction problems with phase change. The scheme requires a very small timestep because of its conditional stability, but, as no matrix inversion is required, the cost per timestep is an order of magnitude lower than for a conventional scheme.The principles of using object-oriented techniques for general finite element programming are briefly explained, while the advantages for parallel processing are described in detail, including the classes used to perform message passing.An example is given showing the performance of the scheme on two completely different parallel machines: a shared memory Silicon Graphics Power Challenge, and a distributed memory Cray T3D. The results indicate that the program scales efficiently for large meshes. © 1997 John Wiley & Sons, Ltd.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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