Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 597 (1980), S. 384-390 
    ISSN: 0005-2736
    Keywords: (Na^+ channel, R. esculenta) ; Myelinated nerve fiber ; Phenobarbital ; Voltage clamp
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-2013
    Keywords: Myelinated nerve ; Motor fibre ; Sensory fibre ; Voltage clamp ; Na inactivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Development of Na permeability inactivation was investigated in myelinated motor (N=12) and sensory (N=12) nerve fibres ofRana esculenta at 20° C. The K currents were blocked by 10 mM tetraethylammoniumchloride, added to the superfusing solution. Additionally, in 4 fibres of each group internal CsCl was applied by diffusion from the cut internodes. Development of Na inactivation was approximated by the sum of two exponentials. The time constants of the fast and slow inactivation phase (σh1 and σh2) were dependent on membrane potential (E) with similar values in both fibre types for a given E. In contrast, significant differences were found in the contribution of both phases. In motor nerve fibres the amplitude of the fast phase wasg=0.70 (mean value of 12 fibres) throughout the potential range investigated (−30 mV≤E≤40 mV). In sensory fibres g was potential dependent, increasing from 0.76 (mean value of 12 fibres) at E=−30 mV to unity at E〉30 mV. This difference in Na permeability inactivation is a further distinguishing property between motor and sensory nerve fibres.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 55 (1984), S. 158-166 
    ISSN: 1432-1106
    Keywords: C-nociceptor ; Pain ratings ; Microelectroneurography ; Man ; Signal detection theory ; CO2 laser stimuli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microelectroneurographic studies in man allow the comparison of stimulus induced activity in the single peripheral nerve unit with the subject's ratings of sensation. Relationships between stimulus intensity, single unit discharges, and pain ratings were investigated using a CO2 laser stimulator which delivers radiant heat pulses of 50 ms duration. Recordings were performed percutaneously from the radial nerve at the wrist. Receptor types were identified by their response to different stimulus modalities and by their reaction delay to electrical test stimuli within the receptive field. Receptive fields of identified units were stimulated with randomised series of different radiant heat intensities between half and double the individual pain threshold (5 to 20 W; stimulation area 64 mm2). The largest receptor class observed to be activated by CO2 laser stimuli were polymodal C-nociceptors. None of them was spontaneously active. High discharge rates up to 75/s were not necessarily associated with pain but, if pain was felt, the impulse trains usually lasted for more than 60 ms. Inter-spike intervals were distributed over a wide range between 8 and 145 ms with a peak at about 25 ms. This peak was only slightly shifted by increasing the stimulus intensity. Higher correlations were found between the number of spikes and stimulus intensity. Measures of Signal Detection Theory indicated that the single unit discharges discriminated stimulus intensities better than the subjects' ratings. These findings underline the importance of temporal summation in the processing of C-fibre input with a considerable loss of information in the nociceptive system.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...