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  • 1
    Electronic Resource
    Electronic Resource
    Chromatographic resolution of chiral intermediates in β-adrenergic blocker synthesis on chiral stationary phases (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 5 (1993), S. 554-559 
    Details
    ISSN: 0899-0042
    Keywords: HPLC ; chiral stationary phases ; resolution of enantiomers ; β-adrenergic blockers ; alcohols ; acetates ; Chiralcel OB ; Chiralcel OD ; Chiralpak OT(+) ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The enantiomeric purities of optically active intermediates for β-adrenergic blocking agents prepared via enzyme-assisted processes can be determined rapidly and with high accuracy using HPLC on commercially available columns with chiral supports [Chiralcel OD, OB; Chiralpak OT(+)]. The dependence of the resolution parameters on the substitution pattern of both hydroxy compounds and their esters is reported. © 1993 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530050712
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Shape selectivity assessment of stationary phases in gas chromatography (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Microcolumn Separations 6 (1994), S. 115-125 
    Details
    ISSN: 1040-7685
    Keywords: gas chromatography ; stationary phases ; liquid crystal polysiloxane ; C18 polysiloxane ; shape selectivity ; polycyclic aromatic hydrocarbons ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Column selectivity is examined for a series of smectic liquid crystalline columns and is compared with methyl and C18 polysiloxane columns for the separation of polycyclic aromatic hydrocarbon (PAH) isomers. A set of extended and condensed solute probes is described that provides a sensitive indication of variations in column shape selectivity. Examples of shape selectivity differences are presented for smectic liquid crystalline columns and 5% phenyl polysiloxane columns using various PAH isomer sets. Variations in selectivity have been observed among different smectic liquid crystalline columns, and this problem appears more significant than for methyl polysiloxane columns. The selectivity ration for tetraphenylmethane and p-terphenyl provides a sensitive indication of column shape selectivity, with a change in elution order occurring between ordered (smectic liquid crystalline) columns and non-ordered (methyl polysiloxane) columns. Shape selectivity differences indicated by this test mixture are apparent for more complex PAH isomer mixtures. Despite stationary phase selectivity variability, smectic liquid crystalline columns offer considerable potential for solving difficult separation problems involving structured solutes.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mcs.1220060205
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    Paper (German National Licenses)
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