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  • 1
    Electronic Resource
    Electronic Resource
    15-Hydroxyeicosatetraenoic acid (15-HETE) specifically inhibits the LTB4-induced skin response (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 401-405 
    Details
    ISSN: 1432-069X
    Keywords: 15-HETE ; Leukotriene B4 ; C5a
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 15-Hydroxyeicosatetraenoic acid (15-HETE), a 15-lipoxygenase product of arachidonic acid, inhibits leukotriene B4 (LTB4)-induced chemotaxis of polymorphonuclear leukocytes (PMNs) in vitro. In this study the effects of intradermal injections of LTB4 were determined in the absence or presence of 15-HETE. For comparison intradermal injections of purified human complement split product C5a were performed in the absence or presence of 15-HETE. The skin response was evaluated by measuring the diameter of the wheal, the area of the flare and by intensity of the erythema (erythema index). LTB4 and C5a were injected at the concentration of 200 ng/ml. At this concentration the maximal skin response of LTB4 and C5a were equivalent. In contrast to C5a reaction, which resolved within 1 h, LTB4-induced skin response lasted up to 18 h. In all subjects the skin response was significantly decreased when LTB4 was injected together with 300 ng of 15-HETE. The decrease of wheal, flare, and erythema index averaged 81.9%, 56.6%, 53.6%, respectively, when all parameters were obtained at the maximal skin response. In contrast, the C5a-induced skin response was not affected by addition of 15-HETE, even when the final dose of 15-HETE was increased 10 times to 3 μg. The LTB4-induced reaction could last up to 18 h after injection. After the addition of 300 ng of 15-HETE the skin response resolved after 1 h. The present results demonstrate that 15-HETE is a specific inhibitor of the LTB4-induced skin response and brings additional evidence in support of the ability of 15-HETE to regulate the proinflammatory effects of LTB4 in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455325
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  • 2
    Electronic Resource
    Electronic Resource
    Flow-induced crystallization of polypropylene in stretched ribbons (1976)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 16 (1976), S. 217-221 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Ribbons of molten polypropylene have been extruded into a thermostatted chamber and subjected to elongations ranging as high as 4400-fold. Some of these ribbons have been shown to possess the unusual ability of recovering nearly all of the strain from large levels of stretch (≤100 percent). This property, as well as the magnitude of the tensile yield drop, has been found to be directly proportional to the uniaxial character of the flow present at the moment of crystallization. The structure in the final solid films has been characterized by wide angle X-ray diffraction and crystal orientation distribution. Both of these factors have been found to be proportional to the character of flow at the moment of crystallization. Finally, the temperature in the thermostatted chamber has been shown to affect the character of the flow.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760160316
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  • 3
    Electronic Resource
    Electronic Resource
    Crystal nucleation in sheared polymer melts (1978)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 18 (1978), S. 215-221 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A semiquantitative procedure has been developed for analyzing crystal nucleation in undercooled polymer melts that are undergoing flow. This analysis was applied to the specific ease of molten high density polyethylene experiencing low levels of shearing flow. A custom-made concentric cylinder viscometer, which could be operated by the Rheometrics mechanical spectrometer instrument, was used to make simultaneous measurements of transmitted torque and optical anisotropy in isothermal melts, The result of the analytical procedure developed here was molecular Size-dependence of chain distensions caused by prevailing shear. This distribution function was verified by testing against experimentally obtained values of birefringence. Total entropy reduction resulting from this distorted state was then calculated, and the corresponding increase in free energy was found to be at least enough to account for comparable crystal nucleation rates in flowing melts at higher temperatures and in quiescent melts at lower temperatures.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760180308
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    Paper (German National Licenses)
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