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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of intelligent manufacturing 3 (1992), S. 109-122 
    ISSN: 1572-8145
    Keywords: process planning ; CAD ; CAM
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In this paper, we describe our development of a fully integrated manufacturing planning assistant (IMPA) system, which is able to: (1) interpret the finished part requirements directly from the designer's CAD systems or solid modelers without user intervention or special feature coding; (2) check the machinability of a designed part; (3) automatically generate a process plan, a tool path and an NC (numerically controlled) code, and (4) support interactive user modification of the resulting plans, tool paths and NC code. A demonstration version of the system was designed to provide automated assistance for the planning of machining processes on three-axes NC machine tools. The underlying architectural concepts and reasoning algorithms can be extended to more complex machines such as four-or-more-axes NC machines. CAD, CAE, and CAM including robotic, FMS (flexible manufacturing system) and NC machines are widely used in industry today. There is increasing interest in automation of factory control software Merchant, (1988); this includes automating the generation of the control programs — that is, in developing systems which will automatically produce the NC code for machining the part, given a model of the part, the shape of the raw material, and the machine specifications. With such systems, there are several difficulties in the manual preparation of an NC program code such as, long and tedious calculations, high risk of error in data preparation, etc., which need to be eliminated. This is a critical step toward the integration of CAD and CAM into a truly concurrent engineering and manufacturing environment.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 240 (1993), S. 144-148 
    ISSN: 1432-1459
    Keywords: Ceruletide ; Cholecystokinin ; Thalamic tremor ; Action tremor ; Posteroventral lateral nucleus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two men, aged 63 and 71 years, developed a gross action tremor and dysesthesias several months after an intracerebral hemorrhage. CT and MRI showed a small hemorrhage in the posterior region of the lateral nucleus of the thalamus in each patient. The tremor occurred on movement, had frequencies of 2.5-4.5 Hz and the amplitude varied depending on the joint position of the limb. Ceruletide (a cholecystokinin analog) 0.8 μg/kg i.m. produced a marked reduction in the action tremor and improved motor function. This effect appeared 10 15 min after the injection, and lasted for up to 4 weeks. It is suggested that ceruletide may be of value in the treatment of action tremors following a thalamic lesion.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 241 (1994), S. 573-576 
    ISSN: 1432-1459
    Keywords: Axon reflex ; Ceruletide ; Parkinson's disease ; Sweat function ; Sympathetic skin response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sweat function was studied in patients with Parkinson's disease and in normal adults by sympathetic skin response, the bromphenol blue printing method and the silicone mould method. In patients with Parkinson's disease, dysfunction of sweating was classified into two types: one type involved the postganglionic fibres and the other involved the preganglionic fibres or the central nervous system. The latter was observed in patients with milder disease and the former was observed in patients with severe disease. The progressive involvement of sweat function in Parkinson's disease may reflect spread from the central nervous system or preganglionic fibres to postganglionic fibres. In a few patients the results of sweat tests were normal. Ceruletide increased sweating in Parkinson's disease patients, and decreased the prolonged latency of the sympathetic skin response. It is hypothesized that ceruletide facilitates the preserved somatosympathetic reflex of sweating.
    Type of Medium: Electronic Resource
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