ISSN:
1432-2277
Keywords:
Rejection, CD18 receptors, rabbit heart
;
Rejection, ICAM-1 ligands, rabbit heart
;
CD18 receptors, rejection, rabbit heart
;
ICAM-1 ligand, rejection, rabbit heart
;
Rabbit, rejection, heart
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Building evidence suggests that blocking the ICAM-1/CD18 interaction may affect the course of graft rejection. Treatment with monoclonal antibody (mAb) to CD18 was compared to antibody to ICAM-1 in a rabbit heterotopic heart transplant model to determine whether blocking the leukocyte receptor for ICAM-1, CD18, was more effective than antibody targeting of the ligand for ICAM-1. Following transplantation, 28 recipient rabbits were randomized to receive either placebo, mAb to CD18, or mAb to ICAM-1 for 7 days until sacrifice. The cellular rejection grade and percentage of arteries with vascular rejection were significantly lower in animals treated with anti-CD18 than with anti-ICAM-1. As assessed by histology, antibody treatment was more effective in reducing both cellular and vascular rejection when directed at the leukocyte receptor CD18 than the ICAM-1 ligand. These findings suggest that other ICAM ligands may play an active role in the immune response and that CD18 may be important for migration of lymphocytes through myocardium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00335597
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