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  • CH3SH  (1)
  • Cardiac surgery  (1)
  • Hot-wire anemometer  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Inhaled prostacyclin and platelet function after cardiac surgery and cardiopulmonary bypass (2000)
    Springer
    Intensive care medicine 26 (2000), S. 188-194 
    Details
    ISSN: 1432-1238
    Keywords: Key words Aerosol ; Prostacyclin ; Platelet function ; Cardiac surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To study the effects of 6 h inhalation of aerosolized prostacyclin (PGI2) on platelet function.¶Design: In a prospective, double-blind, randomized study, 28 patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB), received either 0.9 % sodium chloride (n = 8), PGI2 5 μg × ml–1 (n = 10) or PGI2 10 μg × ml–1 (n = 10) as an aerosol for 6 h postoperatively.¶Setting: Cardiothoracic intensive care unit at a university hospital.¶Interventions: All patients were studied immediately after surgery during mechanical ventilation and sedation. The PGI2 solutions or saline were administered with a jet nebulizer.¶Measurements and results: Bleeding time and chest tube drainage were measured. Blood samples for platelet aggregation, thrombelastography (TEG) and analysis of coagulation parameters and the stable prostacyclin metabolite 6-keto-PGF1α were obtained immediately before inhalation and after 2, 4 and 6 h of inhalation. After 6 h of PGI2 inhalation, regardless of administered dose, there was a lower rate of platelet aggregation and a lower maximal increase in light transmission in response to adenosine diphosphate (ADP) than in the control group. The TEG variable reaction time (R) was prolonged after 4 and 6 h of inhalation in the PGI2 group receiving 10 μg × ml–1. There were no differences between groups with respect to bleeding time and chest tube drainage or any of the other variables examined.¶Conclusion: Inhalation of PGI2 for 6 h in patients after cardiac surgery is associated with impaired platelet aggregation detected by in vitro techniques, with no in vivo signs of platelet dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050044
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Products and mechanisms of the gas phase reactions of NO3 with CH3SCH3, CD3SCD3, CH3SH and CH3SSCH3 (1992)
    Springer
    Journal of atmospheric chemistry 14 (1992), S. 95-108 
    Details
    ISSN: 1573-0662
    Keywords: Products ; mechanism ; NO3 ; gas phase ; CH3SCH3 ; CD3SCD3 ; CH3SH ; CH3SSCH3 ; isotope effect ; air ; troposphere
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Products and mechanisms of the reaction between the nitrate radical (NO3) and three of the most abundant reduced organic sulphur compounds in the atmosphere (CH3SCH3, CH3SH and CH3SSCH3), have been studied in a 480 L reaction chamber using in situ FT-IR and ion chromatography as analytical techniques. In the three reactions, methanesulphonic acid was found to be the most abundant sulphur containing product. In addition the stable products SO2, H2SO4, CH2O, and CH3ONO2 were identified and quantified and thionitric acid-S-methyl ester (CH3SNO2) was observed in the i.r. spectrum from all of the three reactions. Deuterated dimethylsulphide (CD3SCD3) showed an isotope effect on the reaction Deuterated dimethylsulphide (CD3SCD3) showed an isotope effect on the reaction rate constant (kH/kD) of 3.8±0.6, indicating that hydrogen abstraction is the first step in the NO3+CH3SCH3 reaction, probably after the formation of an inital adduct. Based on the products and intermediates identified, reaction mechanisms are proposed for the three reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00115226
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Evaluation of a constant-temperature hot-wire anemometer for respiratory-gas-flow measurements (1979)
    Springer
    Medical & biological engineering & computing 17 (1979), S. 211-215 
    Details
    ISSN: 1741-0444
    Keywords: Hot-wire anemometer ; Respiratory-gas-flow measurements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The performance of a constant-temperature hot-wire anemometer for respiratory-gas-flow measurement has bee investigated. It is shown that the anemometer satisfies common demands with respect to accuracy, response time and to insensitivity to humidity and temperature variations. A calibration method is suggested that permits correction for variation of the flowmeter signal caused by changes of the gas composition. Finally, a procedure for linearisation of the flowmeter signal as a function of flow rate is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02440931
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    Paper (German National Licenses)
    Fulltext
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