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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Environmental Pollution 84 (1994), S. 197-202 
    ISSN: 0269-7491
    Keywords: COD ; PAC ; PAH ; hydrocarbons ; tissues
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Infant Behavior and Development 9 (1986), S. 283-290 
    ISSN: 0163-6383
    Keywords: heart rate ; motor activity ; premature infants
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 27 (1984), S. 209-215 
    ISSN: 1432-1041
    Keywords: propranolol ; hepatic drug disposition ; rat liver perfusion ; pharmacokinetics in man ; heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Studies were conducted to determine the mechanism whereby ethanol alters the hepatic disposition of propranolol. In eight isolated perfused rat livers, ethanol ( $$\bar x$$ =40.1 mmol/l diminished the clearance of dl-propranolol (1.93±0.43 to 1.24±0.22 ml/min/g liver, p〈0.05); increased its t1/2 (12.8±1.5 to 20.7±3.25 min, p〈0.01); and decreased the proportion metabolized (68.7±4.7% to 34.3±10.3%, p〈0.01). These results suggest that ethanol could substantially increase the oral bioavailability of propranolol in humans. However, in normal human volunteers administered 80 mg of propranolol orally, alone, or preceded and followed by ethanol to maintain breath ethanol concentrations of 800–1000 mg/l, increases in propranolol AUC were smaller than anticipated. Seven subjects had increases in free propranolol AUC0–8h (32%, range: 12–61%) (p〈0.05), while total propranolol AUC0–8h increased by a mean 22% (range: −4–+49%). Propranolol free fraction varied with time and was higher after ethanol ( $$\bar x$$ =0.090 vs 0.084) (p〈0.077). The extent of the propranolol-induced slowing of heart rate was not influenced by ethanol (mean decrease from baseline of 13 bpm at peak propranolol effect vs 9 bpm without ethanol); mean heart rates following propranolol with ethanol were higher at all times (mean of 7.5 bpm) (p〈0.001) than after propranolol alone. Ethanol inhibits the hepatic oxidative metabolism of propranolol in vitro; however, any effect on heart rate of higher concentrations of propranolol induced by ethanol in humans is off-set by the cardio-acceleratory effect of ethanol.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 2 (1962), S. 139-139 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 4 (1964), S. 107-112 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Studies of capillary extrusion measurements using an Instron rheometer show that certain types of high density polyethylene exhibit a discontinuity in the shear stress/shear rate curve. This behavior which is separate and distinct from the phenomenon of melt fracture is caused by a change in the flow regime. It is manifested by oscillation of the recorded load while the rheometer piston is operated at a constant rate. Therefore, this behavior has been termed “oscillating shear phenomenon”. The location and magnitude of the fluctuations are functions of the molecular parameters of the polymer as well as the melt temperature, capillary geometry, and other rheometer variables. Evidence is presented which indicates that the change in flow regime could result from the orientation of the melt as it enters the capillary.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 3 (1963), S. 21-26 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Attempts to operate plastic processing equipment at higher production rates is often accompanied by erratic flow behavior of the polymer melts. In order to study this problem, a constant-rate, capillary rheometer was used to study the melt flow over a wide range of shear rates. These data demonstrate that many high-density polyethylenes exhibit a discontinuous shear-stress shear-rate curve; that is, under certain conditions the observed load oscillates “between two values differing by about 15%”. This region of unstable melt flow is not necessarily allied with melt fracture although it is dependent on molecular weight and melt temperature. Unstable melt flow occurs at lower shear rates with a decrease in the melt index (increase in molecular weight) or melt temperature.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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