ISSN:
1432-1246
Keywords:
Lead in blood
;
Lead in tissues
;
ALAD in blood
;
ALAD in tissues
;
Porphyrins in blood
;
Porphyrins in tissues
;
Transplacental transfer
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Lead was administered to three groups of 4 weeks-old female rats at the dose of 1 ppm in drinking water. The first group received lead continuously for 150 days before mating (with non-lead-treated male rats), during pregnancy and during 3 weeks after delivery. In the second group lead was also administered for 150 days before mating but was withdrawn during pregnancy and during the post natal period. In the third group lead was administered for 150 days; the animals were then kept without lead exposure during the 50 days before making them pregnant, during pregnancy and during the post natal period. A control group received only demineralized water. On day 21 after delivery the mothers and their newborns were sacrificed and various parameters of blood-lead concentration (Pb-B), hematocrit (Htc), hemoglobin (Hb), free erythrocyte porphyrins concentration (FEP), σ-aminolevulina-ate dehydratase activity (ALAD) — and tissues — ALAD, free tissue porphyrins (FTP), lead concentration (Pb-T) - were determined. In mothers and in newborns lead concentration in blood and in soft tissues were increased over control values only in the group in which lead had been stopped for 50 days before pregnancy. This lead accumulation in soft tissues was associated with an increased FTP in liver, heart and brain of the mothers and in liver of the newborns. This observation suggests that lead stored in the organism can be mobilized during pregnancy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00435515
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