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  • 1
    Electronic Resource
    Electronic Resource
    Isolation andin Situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematodeCaenorhabditis elegans (1994)
    Springer
    Cellular and molecular neurobiology 14 (1994), S. 9-25 
    Details
    ISSN: 1573-6830
    Keywords: Kex2 ; prohormone convertase (PC) ; endoprotease ; PC2 ; neuropeptide ; Caenorhabditis elegans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. A cDNA that encodes a Kex2-like prohormone convertase (PC) containing an active site similar to that of mammalian PC2 has been isolated fromC. elegans. Total RNA was isolated from a mixed population of strain BA713 worms. After poly-(A)-selection and reverse transcription, degenerate/nested polymerase chain reactions (PCR) were performed using primers based on conserved regions within the active sites of the known vertebrate and invertebrate endoproteases. 2. Two distinct 300-bp PCR products that shared homologies with the active sites of known Kex2-like endoproteases were isolated. These two PCR products were used to screen aC. elegans cDNA library. 3. The complete cDNA for a Kex2-like endoprotease, designated CELPC2, was isolated and determined to be 2527 bp in length. This size was confirmed by northern analysis. The deduced amino acid sequence for the CELPC2 cDNA is very similar to the known Kex2-like endoproteases, especially at conserved regions within the active sites, but not identical to any one of them. The strongest structural homology was to vertebrate and invertebrate PC2 sequences. 4.In situ hybridization suggests that CELPC2 is synthesized primarily in cells associated with the circumpharyngeal nerve ring and the dorsorectal ganglion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088586
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Understanding acute psychological distress following natural disaster (1994)
    Springer
    Journal of traumatic stress 7 (1994), S. 257-273 
    Details
    ISSN: 1573-6598
    Keywords: disaster ; psychological distress ; theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract A household probability sample of 229 adults was interviewed four to seven months after the Sierra Madre earthquake (June 28, 1991; Los Angeles County). The study predicted psychological distress from these variables: demographics, traumatic event history, low magnitude event history, earthquake related threat perceptions, and earthquake related resource loss. Based on the Conservation of Resources (COR) stress model, it was predicted that resource loss would be central in predicting psychological distress. Three major hypotheses were supported: (1) resource loss was positively associated with psychological distress; (2) resource loss predicted psychological distress when other predictors were statistically controlled; and (3) resource loss was associated with mild to moderate elevations in of psychological distress. The findings support COR stress theory. Theoretical and practical implications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02102947
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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