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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural and electron immunohistochemical features of medullary thyroid carcinoma (1989)
    Springer
    Virchows Archiv 414 (1989), S. 375-384 
    Details
    ISSN: 1432-2307
    Keywords: Thyroid neoplasms ; Electron microscopy ; Immunohistochemistry ; Calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ultrastructural study, both morphological and immunohistochemical, has been carried out on eight thyroglobulin-positive and nine thyroglobulin-negative medullary carcinomas of the thyroid. The morphometric analysis of granule size showed that all tumours contained cells with small granules and cells with medium size granules, whereas eight tumours had additional cells with large granules. The small granules had an electron dense core, while the medium and large sized granules were both pale-cored and dense-cored. The cells with small, medium or large secretory granules were all immunoreactive for calcitonin and CGRP. No ultrastructural differences were observed between thyroglobulin-positive and thyroglobulin-negative cases of medullary carcinoma of the thyroid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00718620
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Prognosefaktoren bei differenzierten Schilddrüsenkarzinomen (1997)
    Springer
    Der Pathologe 18 (1997), S. 275-285 
    Details
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Schilddrüse ; Karzinome ; Prognose ; Pathologie ; Histologie ; Key words Thyroid ; Carcinoma ; Prognosis ; Pathology ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This review aims at describing the influence of established and not yet sufficiently characterized parameters on the prognosis of thyroid follicle cell carcinomas. The analysis of literature data covers a broad spectrum of pathologic and biologic factors from classical prognostic features like age, gender and tumor stage to mutation, activation or, where applicable, inactivation of tumor suppressor genes, metastasis-related genes and adhesion molecules.
    Notes: Zusammenfassung Der Einfluß etablierter und noch nicht abschließend beurteilbarer Parameter auf die Prognose von Follikelzellkarzinomen der Schilddrüse wird dargestellt. Das Spektrum der in dieser umfangreichen Literaturanalyse enthaltenen pathologischen und biologischen Faktoren reicht von klassischen Prognosemerkmalen wie Alter, Geschlecht und Tumorstadium bis hin zur Mutation bzw. Aktivierung oder Inaktivierung von Tumorsuppressor-Genen, Metastasierungs-assoziierten Genen und Adhäsionsmolekülen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002920050217
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    Paper (German National Licenses)
    Fulltext
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