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  • Caloric stimulation  (1)
  • Escherichia coli endotoxin  (1)
  • Fluctuating hearing  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 253 (1996), S. 425-428 
    ISSN: 1434-4726
    Keywords: Endolymphatic sac ; Fluctuating hearing ; Large vestibular aqueducts ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The vestibular aqueduct (VA) and endolymphatic sac (ES) were examined by magnetic resonance imaging in eight patients (14 ears) with large VAs, and the results were compared with those obtained in five normal volunteers (10 ears). It was not possible to identify either the VA or ES in any of the control ears. However, in all the 14 ears with a large VA, the VA was detected as a fluid-filled structure. In 12 ears the ES was seen to be markedly enlarged and also filled with fluid. In one ear, the volume of the fluid-filled space within the VA and ES was measured as 912 mm3 on serial images. Five patients (ten ears) were observed to have a fluid-filled VA and enlarged ES without cochlear anomalies and reported frequent episodes of sudden hearing loss and vertigo following exercise, long exposure to sunshine, minor trauma and the like. Two other patients (three ears) also had enlarged VA and ES as well as cochlear anomalies, but did not have episodes of sudden hearing loss and vertigo. These findings suggest that direct transmission of intracranial pressure changes to the inner ear or subsequent movement of endolymph in patients with a large VA may adversely influence a seemingly normal cochlea and vestibule.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 251 (1994), S. 48-51 
    ISSN: 1434-4726
    Keywords: Caloric stimulation ; Scarpa's ganglion ; Static tilt ; Coefficient of variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of caloric stimulation on the primary vestibular fibers originating from the otolith organ was investigated in the guinea pig. Firing rates were recorded from single vestibular neurons in the superior vestibular (Scarpa's) ganglion which were identified physiologically as originating from the otolith organs, mainly from the utricles. Eighty-six percent of the neurons responded to caloric stimulation. Neurons with a high coefficient of variation of firing regularity reacted more sensitively to tilting and also had a tendency to react more sensitively to caloric stimulation. There was a tendency for neurons with increased firing rates in response to ipsilateral tilting to have increased firing rates to warm stimulation, while neurons whose rates increased to contralateral tilting had increased firing rates to cold stimulation. These results indicate that the otolith organs have the same unidirectional tendency to caloric simulation with results comparable to optimal tilting directions.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 247 (1990), S. 89-92 
    ISSN: 1434-4726
    Keywords: Otitis media with effusion ; Eustachian tube dysfunction ; Escherichia coli endotoxin ; Animal experiment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this study was to investigate sufficient conditions for the development of long-lasting otitis media with effusion (OME) without any organic obstruction of the eustachian tube. Three experimental conditions were employed using 20 adult cats (27 ears). Only tubal ventilatory dysfunction with transection of the tensor veli palatini muscle and excision of the pterygoid hamulus resulted in a small incidence of OME (7.1%), which lasted for 5 weeks. Instillation of Escherichia coli endotoxin into the middle ears formed only a transient OME in 50% of the animals. Combination of these two procedures brought a high incidence of OME (85.7%), most of which lasted for more than 8 weeks. These studies showed that tubal ventilatory dysfunction alone was not a sufficient condition for the development of OME but was important for prolongation of the pathological state of OME. The production of inflammatory exudate was considered to be a trigger for the formation of OME.
    Type of Medium: Electronic Resource
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