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  • 1
    Electronic Resource
    Electronic Resource
    Dementia with Lewy bodies: a study of post-synaptic dopaminergic receptors with iodine-123 iodobenzamide single-photon mission tomography (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 609-614 
    Details
    ISSN: 1619-7089
    Keywords: Dementia with Lewy bodies ; Alzheimer's disease ; D2 receptors ; Iodine-123 iodobenzamide ; Single-photon emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dementia with Lewy bodies (DLB) can at present only be diagnosed with certainty by neuropathological examination. Diagnosis during life remains at best probable, based on the presence of symptoms known from autopsy studies to be frequently associated with DLB. The greatest practical clinical problem lies in distinguishing DLB arid Alzheimer's disease (AD). In DLB there is a considerable degeneration of nigral neurones with depletion of striatal dopamine. In contrast, AD is not associated with significant changes in dopamine metabolism. Iodine-123 iodobenzamide single-photon emission tomography (IBZM-SPET) measures post-synaptic dopamine D2 neuroreceptor availability in the corpus striatum, but is nevertheless a method for assessing the integrity of the nigrostriatal dopaminergic pathway. Sixteen clinically diagnosed DLB patients, 15 normal controls arid 13 AD patients underwent IBZM-SPET. All subjects were scanned 1.5–2 h after intravenous injection of 185 MBq of123I-IBZM. Circular regions of iriterest were employed to calculate radioactivity ratios in each hemisphere as follows: caudate nucleus/frontal cortex, putamen/frontal cortex arid caudate nucleus/putamen. The DLB patients had significantly lower left caudate/putamen ratios (95% confidence intervals: DLB 0.893–0.965, AD 0.972–1.175, controls 1.031–1.168) than either controls or AD patients, and significantly lower right caudate/putamen ratios (95% confidence intervals: DLB 0.926–1.019, AD 0.954–1.103, controls 1.027–1.144) chan controls. Our data suggest that patients with DLB diagnosed by clinical criteria have changes in striatal post-synaptic D2 receptors. This may be of value in distinguishing DLB from AD during life.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00841397
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  • 2
    Electronic Resource
    Electronic Resource
    Allelopathic actions of the alkaloid 12-epi-hapalindole E isonitrile and calothrixin A from cyanobacteria of the genera Fischerella and Calothrix (2000)
    Springer
    Journal of applied phycology 12 (2000), S. 409-416 
    Details
    ISSN: 1573-5176
    Keywords: cyanobacteria ; bioactive compounds ; allelopathy ; calothrixin ; hapalindole ; alkaloids ; Fischerella ; Calothrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The alkaloids 12-epi-hapalindole E isonitrile,isolated from the cyanobacterium Fischerellasp., and the indolophenanthridine calothrixin A, fromCalothrix sp., were characterized in terms oftheir ability to kill several organisms and celltypes, and their biochemical modes of action. Bothcompounds inhibited RNA synthesis, and consequentlyprotein synthesis, in Bacillus subtilis. Calothrixin A also inhibited DNA replication, thehapalindole having little effect on this process. Measurements of in vitro RNA synthesis confirmedthe in vivo results and suggested that bothcompounds inhibit RNA polymerase directly; the degreeof inhibition was independent of the DNAconcentration, but strongly dependent on thepolymerase concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008170007044
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  • 3
    Electronic Resource
    Electronic Resource
    Volume changes during stress relaxation in polyethylene (1995)
    Springer
    Rheologica acta 34 (1995), S. 182-195 
    Details
    ISSN: 1435-1528
    Keywords: Stress dilatometry ; polyethylene ; stress relaxation ; Grüneisen parameter ; physical ageing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Abstract This paper presents the results of an experimental study of the stress relaxation behaviour of PE where the focus was on determination of the volume changes taking place during the relaxation process. The dimensions of the samples were followed using a specially designed non-disturbing extensometer. The extensometer data were confirmed in experiments where the volume was measured with a specially designed liquid stress dilatometer. The bulk of the results was obtained with LDPE and LLDPE. High density polyethylene was shown to behave similarly. The decrease in volume, corresponding to an increasing Poisson's ratio, during relaxation was approximately linear with log time. Volume vs. stress diagrams were linear; the values of the apparent bulk modulus calculated from them were only slightly higher than those obtained from the stress-strain curves. Grüneisen parameter was measured and compared with reported values. Possible similarities between the volume change during stress relaxation and that occuring during the process of physical ageing are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00398438
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    Paper (German National Licenses)
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