ISSN:
1434-0879
Keywords:
Cancer chemotherapy
;
Vesical absorption
;
Adriamycin
;
Thiotepa
;
Daunomycin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The permeability of the bladder mucosa to thiotepa and to the anthraquinonic antibiotics, adriamycin and daunomycin, was investigated both in humans and in experimental animals. Instillations in rabbits were performed either in intact males or in animals with ligated ureters. Absorption of thiotepa was significantly higher than that of the antibiotics both in men and in rabbits. Furthermore a qualitative difference was observed in rabbits in relation to time and with regard to fixation to vesical tissues. In man, absorption was highest after transurethral surgery. It was also increased in cases with extensive anaplastic tumours or in the presence of acute inflammatory reactions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00256129
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