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  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of the polymerase chain reaction for the detection ofBorrelia burgdorferi in cerebrospinal fluid of children with acute peripheral facial palsy (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 374-377 
    Details
    ISSN: 1432-1076
    Keywords: Lyme borreliosis ; Facial palsy ; Borrelia burgdorferi ; Polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neuroborreliosis occasionally represents a diagnostic problem, especially in the early stage of the infection. The polymerase chain reaction (PCR) offers an attractive alternative to antibody testing. The aim of our study was to investigate the diagnostic potential of PCR in comparison to antibody tests in CSF of children with facial palsy. In contrast to other manifestations of neuroborreliosis, facial palsy is a welldefined clinical entity in which CSF findings allow an early distinction according to aetiology. The study included 17 children with neuroborreliosis, defined by the detection of specific IgM antibodies in CSF, and 20 children with facial palsy of unknown cause. Primers used for the nested PCR were generated from conserved sequences of the OspA-gene. Most of the cases in both subgroups have been examined within a few days after the onset of the paresis. Only in 2 out of 17 cases with neuroborreliosis could specific DNA be amplified. The PCR gave negative results in all cases of the control group. Conclusion The IgM capture ELISA is superior to PCR to support the clinical diagnosis of neuroborreliosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072106
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of the polymerase chain reaction for the detection of Borrelia burgdorferi in cerebrospinal fluid of children with acute peripheral facial palsy (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 374-377 
    Details
    ISSN: 1432-1076
    Keywords: Key words Lyme borreliosis ; Facial palsy ; Borrelia burgdorferi ; Polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neuroborreliosis occasionally represents a diagnostic problem, especially in the early stage of the infection. The polymerase chain reaction (PCR) offers an attractive alternative to antibody testing. The aim of our study was to investigate the diagnostic potential of PCR in comparison to antibody tests in CSF of children with facial palsy. In contrast to other manifestations of neuroborreliosis, facial palsy is a well-defined clinical entity in which CSF findings allow an early distinction according to aetiology. The study included 17 children with neuroborreliosis, defined by the detection of specific IgM antibodies in CSF, and 20 children with facial palsy of unknown cause. Primers used for the nested PCR were generated from conserved sequences of the OspA-gene. Most of the cases in both subgroups have been examined within a few days after the onset of the paresis. Only in 2 out of 17 cases with neuroborreliosis could specific DNA be amplified. The PCR gave negative results in all cases of the control group. Conclusion The IgM capture ELISA is superior to PCR to support the clinical diagnosis of neuroborreliosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050307
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Wirkung von Carbamazepin auf die neurosekretorischen Kerne der Ratte (1970)
    Springer
    Clinical and experimental medicine 153 (1970), S. 95-98 
    Details
    ISSN: 1591-9528
    Keywords: Neurosecretion ; Carbamazepine ; Histochemistry ; Neurosekretion ; Carbamazepin ; Histochemie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Enzyme TPP, NADPH2-D, G6PDH und sPh ließen sich bei Ratten im osmotischen Streß in erhöhter Aktivität nachweisen. Längerer Wasserentzug führte bei den Tieren zu einem fast völligen Schwinden des Neurosekretes. Die Gabe von Carbamazepin hatte weder einen Einfluß auf die Enzymaktivitäten noch auf die Neurosekretproduktion. Die Befunde sprechen dagegen, daß Carbamazepin am Bildungsort des ADH wirksam wird.
    Notes: Summary Due to an osmotic stress rats showed an increased activity of the enzymes thiaminphosphatase, acid phosphatase, NADPH2-diaphorase and glucose-6-phosphat-dehydrogenase in their neurosecretory nuclei. Carbamazepine did not influence these enzyme activities neither in thursting rats nor in those fed regularly. Its antidiuretic effect can therefore not he explained by stimulation of the nucleus supraopticus or paraventricularis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048197
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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