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  • 1
    Electronic Resource
    Electronic Resource
    Weight loss and shock-elicited aggression as indices of morphine abstinence in rats (1975)
    Springer
    Psychopharmacology 45 (1975), S. 157-161 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Naloxone ; Dependence ; Aggression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Weight loss and shock-elicited aggression have been compared as quantitative indices of morphine abstinence in rats. A range of doses of morphine was administered to rats by i.p. injection twice daily for 12–15 days. After injections were stopped, morphine-abstinent rats lost weight precipitously, and showed an increased frequency of fighting in response to aversive stimulation (foot-shock). Recovery of weight appeared complete after 15–20 days but a significant increase in aggression was found at 18 days post-withdrawal; this virtually disappeared after 52 days. Both the amount of weight lost and the frequency of fighting increased as a function of the previous maintenance dose of morphine; the effective dose range appeared similar for these two indices. Weight loss was much less variable than fighting, had the advantage of rapid, objective measurement, and appeared to be the more reliable index of abstinence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429054
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The behavioral effects of a new psychoactive drug (d-Carbine) on a passive avoidance response and locomotion and its interaction with amphetamine (1971)
    Springer
    Psychopharmacology 21 (1971), S. 82-88 
    Details
    ISSN: 1432-2072
    Keywords: Avoidance ; Impairment ; Relationship ; Antagonism ; Synergism ; Imipramine ; Carbidin ; Amphetamine ; Chlorpromazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between amphetamine and a new psychotropic drug, carbidin (in comparison with imipramine and chlorpromazine) was studied on a test of activity and the passiv avoidance conditioned response. Carbidin and imipramine woud appear to differ from chlorpromazine in their mode of action on conditioned response. Looking at the interactions between amphetamine and the other drugs in the two tests differences in the mode of action of carbidin and imipramine becomes apparent. Whereas in the passive avoidance conditioning situation both drugs had similar effects alone and in combination with amphetamine in the activity test, though both are without effect when given alone, in combination with amphetamine the interactions are in opposite directions. Imipramine has a synergistic effect, whereas carbidin has marked antagonistic affect completely reversing the amphetamine induced increase in activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403999
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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