ISSN:
1040-0397
Keywords:
Trinitrobenzenesulfonic acid
;
L-Dopa
;
Carbidopa
;
Methyldopa
;
Aspartame
;
Ion selective electrodes
;
Potentiometry
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A selective PVC membrane electrode based on the ion-pair of cetylpyridinium (CP+) and 2,4,6-trinitrobenzenesulfonate (TNBS-) as the electroactive species was developed. The electrode exhibits a rapid and Nernstian response to TNBS- from 5.0 × 10-5 to 1.0 × 10-2M at 25 ± 0.1°C. The response is unaffected by the change of pH over the range 2-12. Selectivity coefficients for a larger number of organic and inorganic anions and sugars are given. The electrode has been successfully applied to the determination of L-dopa, carbidopa, methyldopa and aspartame in pure solutions and in their pharmaceutical formulations with a precision and accuracy of 0.9-1.3% without interference from excipients.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140081115
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