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  • Life and Medical Sciences  (40)
  • General Chemistry  (21)
  • Carbohydrates  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Structure of the ellipsoid sheath in the spleen of the armadillo (Dasypus novemcinctus). A light and electron microscopic studyThis investigation was supported, in part, by General Research Support grant FR-05409-07 from the College of Medicine, The Ohio State University, Columbus, Ohio. (1970)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 132 (1970), S. 207-223 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The spleen of the armadillo is invested by a capsule composed predominantly of smooth muscle. Inward extensions from the capsule contribute to an extensive system of trabeculae of the non-vascular type. The white pulp presents a typical follicular arrangement and the red pulp is permeated by an anastomosing series of venous sinsuses. The capillary segment of the penicillar artery is invested by an ellipsoid sheath. The spleen of the armadillo may be included in the class of mammalian spleens characterized as sinusal in nature and possessing ellipsoid sheaths. Electron micrographs of thin sections of the sheathed capillaries demonstrate a high-type of endothelium. A characteristic feature of this endothelium is the presence of a distinct intracytoplasmic fibrous component.The reticular cells comprising the sheath proper exhibit various sized vacuoles and inclusion bodies suggestive of their potentially phagocytic nature. In both light and electron microscopy, venous sinuses lie in close proximity to the peripheral cells of the ellipsoid sheaths. Within the wall of the venous sinuses, patent openings are appearent between the lining cells. If such an arrangement exists in the functional state of the organ, it could provide for an additional means of exposure of both plasma and cellular elements to the adjacent phagocytic cells of the sheath proper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051320207
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  • 2
    Electronic Resource
    Electronic Resource
    The marginal zone and marginal sinus in the spleen of the gerbil. A light and electron microscopy studyThis investigation was supported, in part, by a General Research Support grant FR-05409-07 from the College of Medicine, The Ohio State University, Columbus, Ohio. (1973)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 141 (1973), S. 205-215 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The spleen of the adult gerbil (M. unguiculatus) is characterized by the absence of venous sinuses and ellipsoid sheaths. The follicle (white pulp) is separated from the surrounding red pulp by a distinct marginal zone. The cell types in the marginal zone are common to both the follicle and red pulp. Separating the marginal zone from the follicle is a vascular channel of capillary dimension, the marginal sinus. A number of terminal segments of the arterial vessels within the follicle were observed to form a direct connection with the marginal sinus. Ultrastructurally, discontinuities were evident within the walls of the marginal sinus that would permit passage of both cellular and plasma components from the marginal sinus to either marginal zone or the follicle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051410207
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  • 3
    Electronic Resource
    Electronic Resource
    A scanning electron microscopic study of differentiation of the digital pad in regenerating digits of the kenyan reed frog, Hyperolius viridiflavus ferniqueiContribution number 78 from the Amphibian Facility.Supported in part by a grant from the Muscular Dystrophy Associations, Inc. and NIH Grants HD08150 and RR 0572 (1977)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 153 (1977), S. 387-395 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Newly metamorphosed Kenyan reed frogs, Hyperolius viridiflavus ferniquei, are able to regenerate amputated digits. The terminal digital pad is also completely reformed. Differentiation of the regenerating digital pad was studied by scanning electron microscopy. External differentiation of the digital pad began late in the second postamputational week with the appearance of small patches of specialized epidermal cells on the ventral surface of the regenerating digit. The differentiation of the pad spread out radially until late in the fourth week, when its overall shape approximated that of the normal digital pad. The appearance of patches of digital pad epidermis on the ends of spike regenerates arising from the forearm was also confirmed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051530305
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  • 4
    Electronic Resource
    Electronic Resource
    Structural and histochemical aspects of perirenal adipose tissue in fetal pigs: Relationships between stromal-vascular characteristics and fat cell concentration and enzyme activity (1986)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 190 (1986), S. 271-283 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Samples of perirenal adipose tissue were obtained from four fetuses from each of seven crossbred gilts at each of three stages of gestation: 70, 90, and 110 days. Samples were routinely prepared for histochemistry and histology. At each age, the largest fat cell clusters were consistently located near points where large blood vessels entered the loose connective tissue. Cell-cluster size decreased with distance from the entry points of large blood vessels. Fat cells proximal to entry points of large arterioles and fat cells distal to entry points of large arterioles were the same size. Enzyme cytochemistry disclosed that reactions for glucose-6-phosphate dehydrogenose (G6PDH), lipoprotein lipase (LPL) and NADH-TR enzymes were reduced in distal (relative to entry points of large arterioles) adipocytes compared with proximal adipocytes. Reactions for succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH) in adipocytes were not influenced by location within the tissue. Small fat cell clusters with sparse capillary beds surround arterioles in distal areas of sections from fetuses at 70, 90, and 110 days of gestation. In the proximal areas of sections from 110-day-old fetuses, arterioles were surrounded by large fat cell clusters with dense capillary beds. These characteristics serve to distinguish perirenal depots from subcutaneous depots in the fetus.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051900304
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  • 5
    Electronic Resource
    Electronic Resource
    The microscopic structure of the adult raccoon (Procyon lotor) and woodchuck (Marmota monax) spleensThis investigation was supported, in part, by a Public Health Service Research grant 1-FI-CM-22,600-01 (Pre-Doctoral Fellowship) from National Institutes of Health, Bethesda, Maryland. (1967)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 121 (1967), S. 47-54 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Histological serial sections of spleens from the adult raccoon (Procyon lotor) and woodchuck (Marmota monax) were processed for microscopic examination. Observations related to various aspects of the internal vascular pattern in the spleen of the raccoon and woodchuck demonstrated features that were characteristic of the respective animal. The spleen of the raccoon possess well-developed ellipsoid sheaths, whereas these same structures were not as prominent in the spleen of the woodchuck. The spleen of both mammals examined demonstrated the presence of an anastomosing series of venous sinuses within the red pulp tissue and may be classified as sinusal in nature.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051210105
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  • 6
    Electronic Resource
    Electronic Resource
    Studies of a primitive mammalian spleen, the opossum (Didelphis virginiana)This investigation was supported in part by Public Health Service Research grant 5-S01-FR-05409-05 from the National Institutes of Health, General Research Support grant. (1968)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 124 (1968), S. 445-450 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Light microscopic sections of the adult opossum (Didelphis virginiana) spleen were observed to lack venous sinuses; this primitive mammalian spleen may be classified as non-sinusal in nature. In the spleen of the opossum, the capillary segments of the penicillar arteries lacked ellipsoid sheaths characteristic of certain mammalian spleens.Separating the lymphoid nodules from the surrounding red pulp was a distinct band of vascular tissue, the marginal zone. Arising from the central artery within the lymphoid nodule, vessels of capillary dimension were observed to terminate within the marginal zone and the area between lymphoid nodule and marginal zone. In addition to the vascular channels established by the terminal arterial vessels within the red pulp, the system of vessels within the marginal zone has been implicated as an important intermediate vascular channel within the spleen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051240404
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  • 7
    Electronic Resource
    Electronic Resource
    Limb regeneration and survival of prolactin treated hypophysectomized adult newtsSupported by a grant from NSF and NIH grant NB-04128. (1968)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 126 (1968), S. 365-371 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Hypophysectomized adult newts exhibited 98% survival and limb regeneration at 23 days post-hypophysectomy when injected intraperitoneally every other day with prolactin (0.015 U/newt) and kept continuously in aquaria with 1 × 10-7 concentration of thyroxine. Thyroxine alone was no more effective than saline injections.Prolactin (1.2 U/newt every other day) alone increased survival and limb regeneration, but less effectively than did the prolactin-thyroxine combination.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051260306
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  • 8
    Electronic Resource
    Electronic Resource
    Elucidation of Factors Affecting the Electronic Structures of Magnesium(II) and Zinc(II) Tetraarylporphyrin Radical Cations (1995)
    Weinheim : Wiley-Blackwell
    Chemistry - A European Journal 1 (1995), S. 222-231 
    Details
    ISSN: 0947-6539
    Keywords: electronic structure ; frontier orbitals ; metalloporphyrins ; radical cations ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of magnesium and zinc tetraarylporphyrins and their porphyrinoxidized derivatives were studied by UV/Vis, ESR, and resonance Raman spectroscopy at various temperatures. The series included tetra(meta-dichlorophenyl)porphyrinatozinc (5), tetra(ortho-dichlorophenyl)porphyrinatozinc (6), tetra(ortho-difluorophenyl)porphyrinatozinc and -magnesium (9 and 10), and tetra(pentafluorophenyl)porphyrinatozinc and -magnesium (7 and 8). The radical cations (3a-10a) were isolated by chemical one-electron oxidation of their neutral precursors (3-10). Despite the structural similarity of all these radicals, their electronic ground state varied within the series. The position of the chloro groups was found to play a key role. While the radical cation of the meta-dichloro-substituted derivative 5a exhibited A2u spectroscopic features, the ortho-dichlorophenyl derivative (6a) showed A1u spectral features. Radicals of the fluoro-substituted porphyrins, especially that of 10, were found to have state-admixed (A1u/A2u) electronic structures, and the relative contributions of the two states was found to vary with temperature and to depend on the axial ligand. The results indicate that the fluoro-substituted porphyrins are primarily A2u at low temperature, even though their room temperature spectroscopic features resemble those of A1u cations. The elucidation of factors that affect the electronic structures of the radicals in the present series is helpful in providing a greater understanding of the spin-spin interactions in the intermediates of heme-dependant enzymatic reactions and their synthetic analogues.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chem.19950010405
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  • 9
    Electronic Resource
    Electronic Resource
    Glycosyl Phosphatidylinositol (GPI) Anchor Synthesis Based on Versatile Building Blocks - Total Synthesis of a GPI Anchor of Yeast (1999)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1999 (1999), S. 1153-1165 
    Details
    ISSN: 1434-193X
    Keywords: Carbohydrates ; Phospholipids ; Glycolipids ; Sphingosines ; Ceramides ; Ceramides-1-phosphates ; Glycosylation ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -For the design of a synthesis of target molecule 1 the retrosynthetic analysis yielded building blocks 2-5, of which ceramide 2-phosphite derivative 2 and aminoethyl phosphite derivative 5 are known. The generation of α-glucosaminyl (1→6)inositol building block 3 was based on pseudodisaccharide 6 which was selectively benzoylated at 6b-O and then selectively benzylated at 3b-O to give 3. The synthesis of tetramannosyl building block 4 started from known ortho ester derivative 8 which was transformed into versatile mannosyl donors 13 and 18 and into acceptor 22. Reaction of 13 with 22 gave α-disaccharide 23, deacetylation and then mannosylation with 18 gave trisaccharide 25; ensuing deacetylation and mannosylation with 13 gave tetrasaccharide 27; deallylation, acetylation, regioselective removal of the anomeric O-acetyl group and treatment with CCl3CN/DBU afforded 4. Glycosylation of 3 with donor 4 led to pseudohexasaccharide 31 in high yield. Replacement of the O-acyl groups by O-benzyl groups and then exchange of the menthyloxycarbonyl group by an O-acetyl group gave 36 which enabled regioselective attachment of 2 and 5. To this end, the 6e-O-silyl group was removed and then the aminoethyl phosphate residue was attached with reagent 5 to give 38 in high yield. 1a-O-Deacetylation and then reaction with 2 afforded 40 as fully protected 1 which was liberated in two steps; treatment with acid removed all acid labile protective groups and finally catalytic hydrogenation afforded the desired GPI anchor 1 which could be fully structurally assigned.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Hormone-dependent processing of the avian progesterone receptor (1988)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 36 (1988), S. 103-119 
    Details
    ISSN: 0730-2312
    Keywords: progesterone receptor ; avian ; processing ; phosphorylation ; degradation ; antibody probes ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Avian progesterone receptor exists as two forms, A and B, with molecular weights of 79,000 and 110,000 daltons, respectively. The origin and significance of these two forms is an area of active investigation and debate. Monoclonal antibodies produced against these two forms were used to examine receptor stability in cytosol and changes in the receptor forms induced by hormone binding.The lability of hormone binding at elevated temperatures is well documented. Analysis by Western blotting showed the receptor was stable in freshly prepared oviduct cytosol for 2 hr at 37°C, while hormone binding was lost within 30 min. However, loss of receptor through degradation was seen when cytosol was prepared from frozen tissue or when homogenization was excessive.Progesterone was injected into diethylstilbestrol-stimulated chicks to examine, in vivo, effects of hormone treatment on receptor forms in the cytosol and nuclear fractions. Progesterone treatment caused a time- and dose-dependent conversion of the A receptor to a form (A′) with a slower electrophoretic mobility. The cytosolic progesterone receptor was divided equally between the B and A forms, while the nuclear receptor was predominantly A′. The amount of nuclear receptor was consistently less than cytosolic receptor. Receptor phosphorylation was analyzed by incubating tissue minces with [32P]orthophosphate with or without progesterone followed by immune isolation of receptor forms. Progesterone treatment caused a time-dependent increase in cytosol receptor phosphorylation which was evident after 5 min of treatment. This phosphorylation was observed with both the A and B receptor forms. The results indicate that receptor phosphorylation is a very early event during progesterone action.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240360202
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