ZIB

1

Digitale Medien

Induction of stress metabolite formation in suspension cultures of Vigna angularis

Kobayashi, M. ; Ohta, Y.

Amsterdam : Elsevier

Phytochemistry 22 (1983), S. 1257-1261

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ISSN: 0031-9422

Schlagwort(e): Leguminosae ; Vigna angularis ; actinomycin D. ; cell suspension culture ; induction ; isoflavone glucoside ; lignan ; red bean ; stress metabolite

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(83)80235-0

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2

Digitale Medien

Sesquiterpenes of nine european liverworts from the genera, Anastrepta, bazzania, jungermannia, lepidozia and Scapania

Andersen, N.H. ; Bissonette, P. ; Liu, C.-B. ; [weitere]

Amsterdam : Elsevier

Phytochemistry 16 (1971), S. 1731-1751

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ISSN: 0031-9422

Schlagwort(e): Hepaticae ; Jungermanniales ; Scapania ; bazzanene ; cadinene ; chamigrenes ; cis-fused selinenes. ; ent-sesquiterpenes ; gymnomitrol ; himachalene-longifolene-type sesquiterpenes ; myliol ; sibirene ; ylangene

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(71)85081-1

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3

Digitale Medien

Sesquiterpenes of thalloid liverworts of the genera Conocephalum, Lunularia, Metzgeria and Riccardia

Andersen, N.H. ; Ohta, Y. ; Liu, C.-B. ; [weitere]

Amsterdam : Elsevier

Phytochemistry 16 (1971), S. 1727-1729

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ISSN: 0031-9422

Schlagwort(e): Conocephalum ; Hepaticae, cadinene ; Lunularis ; Metzgeria ; Riccardia ; ent-sesquiterpenes ; δ-cadinene.

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(71)85080-X

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4

Digitale Medien

Sesquiterpenes of thalloid liverworts of the genera Conocephalum, Lunularia, Metzgeria and Riccardia

Andersen, N.H. ; Ohta, Y. ; Liu, C.-B. ; [weitere]

Amsterdam : Elsevier

Phytochemistry 16 (1977), S. 1727-1729

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ISSN: 0031-9422

Schlagwort(e): Conocephalum ; Hepaticae, cadinene ; Lunularis ; Metzgeria ; Riccardia ; ent-sesquiterpenes ; δ-cadinene.

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1016/0031-9422(71)85080-X

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5

Digitale Medien

Sesquiterpenes of nine european liverworts from the genera, Anastrepta, bazzania, jungermannia, lepidozia and Scapania

Andersen, N.H. ; Bissonette, P. ; Liu, C.-B. ; [weitere]

Amsterdam : Elsevier

Phytochemistry 16 (1977), S. 1731-1751

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ISSN: 0031-9422

Schlagwort(e): Hepaticae ; Jungermanniales ; Scapania ; bazzanene ; cadinene ; chamigrenes ; cis-fused selinenes. ; ent-sesquiterpenes ; gymnomitrol ; himachalene-longifolene-type sesquiterpenes ; myliol ; sibirene ; ylangene

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1016/0031-9422(71)85081-1

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6

Digitale Medien

Contribution of serum albumin to the transport of orally administered L-tryptophan into liver of rats with L-tryptophan depletion (1999)

Sasaki, E. ; Ohta, Y. ; Shinohara, R. ; [weitere]

Springer

Amino acids 16 (1999), S. 29-39

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ISSN: 1438-2199

Schlagwort(e): Amino acids ; L-Tryptophan ; Serum albumin ; Transport ; L-Tryptophan depletion ; α-Methyl-DL-tryptophan ; Analbuminemic rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The role of serum albumin in the transport of orally administered L-tryptophan (Trp) into rat tissues was examined using analbuminemic and Sprague-Dawley (SD) rats with and without a-methyl-DL-tryptophan (AMT)-induced Trp depletion. Trp was orally administered to rats 16h after AMT or 0.85% NaCl administration, when liver tryptophan 2,3-dioxygenase and protein synthetic activities in AMT-treated rats were similar to those of 0.85% NaCl-treated rats. After oral Trp administration, regardless of the presence or absence of Trp depletion, free serum Trp concentrations were similar in the analbuminemic and SD rats, while total serum Trp concentrations were lower in analbuminemic rats than in SD rats. Although liver, brain, and muscle Trp concentrations after oral Trp administration under Trp depletion were lower in analbuminemic rats than in SD rats, the ratio of the liver Trp concentration in analbuminemic rats to that in SD rats was smaller than that of the brain or muscle Trp concentration. These results suggest that variations in serum albumin levels could affect the transport of orally administered Trp into the liver of rats with Trp depletion.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01318883

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7

Digitale Medien

Change of serum L-tryptophan levels following the development and recovery of acute puromycin aminonucleoside nephrosis in rats (1997)

Sasaki, E. ; Ohta, Y. ; Shinohara, R. ; [weitere]

Springer

Amino acids 12 (1997), S. 353-361

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ISSN: 1438-2199

Schlagwort(e): Amino acids ; L-Tryptophan ; Albumin ; Non-esterified fatty acids ; Puromycin aminonucleoside ; Experimental nephrosis (rat)

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary It is known that total L-tryptophan (Trp) levels decrease with a decrease in albumin-bound Trp levels and an increase in free Trp levels in the plasma or serum of nephrotic children. We, therefore, examined the change of serum Trp levels following the development and recovery of acute nephrosis in 6-week-old male Wistar rats injected once with puromycin aminonucleoside (100mg/kg body weight) and checked the levels of 16 amino acids including Trp in the serum and the levels of Trp in the liver, kidney, and urine under nephrotic conditions. In this study, the development and recovery of nephrosis were checked by the changes of levels of urinary protein and serum protein and albumin. Total serum Trp and albumin-bound serum Trp levels decreased with the development of nephrosis and these decreased levels returned to the normal level with its recovery. In contrast, free serum Trp levels increased with the development of nephrosis and this increased level returned to the normal level with its recovery. In the serum of nephrotic rats, the decrease of albumin-bound Trp levels and the increase of free Trp levels were well consistent with a decrease in albumin levels and an increase in the level of non-esterified fatty acids which are known to weaken the binding of Trp to albumin and among 16 amino acids studied, only Trp showed a significant change in its levels. Trp levels increased in the liver and kidney but not in the urine under nephrotic conditions. These results indicate that the change of serum Trp levels should be closely related to the condition of nephrosis and that although serum Trp is lost under nephrotic conditions, the lost serum Trp is accumulated in the liver and kidney.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01373015

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8

Digitale Medien

Relationship between the level of serum L-tryptophan and its hepatic uptake and metabolism in rats with carbon tetrachloride-induced liver cirrhosis (1996)

Ohta, Y. ; Uemura, M. ; Saito, K. ; [weitere]

Springer

Amino acids 10 (1996), S. 369-378

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ISSN: 1438-2199

Schlagwort(e): L-Tryptophan ; Transport ; Metabolism ; Liver ; Carbon tetrachloride ; Experimental liver cirrhosis (rat)

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary In the serum of rats with liver cirrhosis induced by 12-week intermittent carbon tetrachloride (CCl4) injection, free L-tryptophan (Trp) levels increased with decreases in total Trp, albumin-bound Trp, and albumin levels. In the serum of the cirrhotic rats, there were no changes in the ratio of albumin-bound Trp to albumin and the level of free fatty acids which are known to weaken the binding of Trp to albumin. In the liver of the cirrhotic rats, there were increases in protein and free Trp (i.e., non-protein Trp) contents and a decrease in total tryptophan 2,3-dioxygenase (TDO) activity. The decreased TDO activity was mainly due to the reduction of apo-TDO activity. When [3H]Trp was injected into the portal vein of the cirrhotic and control rats, radioactivity derived from the injected [3H]Trp in the liver was higher in the cirrhotic rats than in the control rats at 10min after the injection, while the radioactivity in the serum was lower in the former rats than in the latter rats. These results indicate that the increased Trp is easily taken up into the cirrhotic liver, and suggest that the Trp taken up into the cirrhotic liver could be utilized for the maintenance of synthesis of proteins in the tissue through the reduction of Trp metabolism due to reduced TDO activity in the tissue.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00805864

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9

Digitale Medien

Enhancement of carbon tetrachloride-induced liver injury by glucagon and insulin treatment (1988)

Masaki, N. ; Yamada, S. ; Ogata, I. ; [weitere]

Springer

Research in experimental medicine 188 (1988), S. 27-33

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ISSN: 1433-8580

Schlagwort(e): Carbon tetrachloride ; Insulin ; Glucagon ; Cytochrome P450

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Rats given a dose of carbon tetrachloride (CCl4) immediately received injections of glucagon and insulin every 4h. They frequently died after 4h and showed a significantly higher mortality between 8h and 28h as compared to the control rats where such deaths occurred 16h later. At 8h, the derangements of SGPT values and prothrombin time were significantly greater in the hormone-treated rats than in the control rats. In these CCl4-intoxicated rats, hepatic reduced glutathione content at 4h was significantly reduced after hormone treatment. The treatment significantly enhanced CCl4 metabolism, conversion of14CCl4 into14CO2 in vitro, by microsomes isolated from the liver, whereas it did not affect the microsomal cytochrome P450 content. These results suggest that glucagon and insulin treatment increased CCl4 hepatotoxicity in rats through activating the cytochrome P450-dependent mono-oxygenase system. This would merit consideration for the clinical application of this treatment.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01852091

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10

Digitale Medien

Partial purification of an endogenous elicitor from suspension-cultured cells of red bean,Vigna angularis (1992)

Phillips, N. ; Imoto, S. ; Ohta, Y. ; [weitere]

Springer

Cellular and molecular life sciences 48 (1992), S. 683-687

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ISSN: 1420-9071

Schlagwort(e): Suspension cells ; Vigna angularis ; UV irradiation ; endogenous elicitor

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract Brief irradiation with a germicidal UV lamp of cells of red bean,Vigna angularis, cultured in suspension in a quartz flask caused the release into the culture medium of an endogenous substance with elicitor activity, as well as the accumulation of isoflavone glucoside stress metabolites in the cells. The active compound was fractionated using phenylalanine ammonia lyase (PAL)-inducing activity in fresh cells as a marker. The elicitor active principle appears to be a low molecular weight (〈2000 MW) water-soluble acidic oligosaccharide.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02118319

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