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  • 1
    Electronic Resource
    Electronic Resource
    The effects of 2,3-butanedione monoxime on initial heat, tension, and aequorin light output of ferret papillary muscles (1990)
    Springer
    Pflügers Archiv 416 (1990), S. 219-221 
    Details
    ISSN: 1432-2013
    Keywords: Cardiac muscle ; butanedione monoxime ; heat production ; aequorin luminescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract At low concentrations (up to 5 mM) the compound 2,3-butanedione monoxime (BDM) was found to reduce twitch tension and initial heat production in isolated papillary muscles without significantly affecting the size of the intracellular Ca transient measured with aequorin luminescence. Higher concentrations of BDM caused further inhibition of twitch tension and heat production with a fall in the size of the Ca+ transient. The size of the aequorin transient was 50% of the control value at 15 mM BDM while twitch tension was negligible. These results suggest that BDM selectively inhibits Ca2+ activated force in cardiac muscle at low concentrations with additional effects on intracellular calcium at concentrations above 5 mM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00370248
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of caffeine and Ca2+ on rigor tension in triton-treated rat ventricular trabeculae (1992)
    Springer
    Pflügers Archiv 421 (1992), S. 343-349 
    Details
    ISSN: 1432-2013
    Keywords: Cardiac muscle ; Rigor tension ; Ca2+ ; Caffeine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ventricular trabeculae from rat heart were chemically skinned with Triton-X100, which disrupts all cellular membranes including the sarcoplasmic reticulum. Trabeculae developed a maintained rigor contracture when adenosine triphosphate was withdrawn from the bathing medium. In all preparations, the final level of rigor force developed in the presence of caffeine (10–40 mM) was greater than under control conditions. However, caffeine failed to increase rigor tension when applied after contracture had fully developed. The effect of caffeine on rigor was maximal at about 15 mM; concentrations greater or less than 15 mM were less effective. On average, caffeine decreased the time required to develop half-maximum rigor force. The caffeine-induced potentiation of rigor force occurred in the effective absence of Ca2+ (10−9 M), in solutions strongly Ca2+-buffered with [ethylenebis(oxonitrilo)]tetraaceticacid (10–50 mM). In all preparations, rigor force was found to be independent of [Ca2+] over the range 10−10 M to about 10−7 M. These results suggest that caffeine affects rigor force by a direct effect on the myofilaments via a mechanism that is independent of Ca2+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374222
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The ultrastructure of the organ of Bellonci of Carcinus maenas (Crustacea: Decapoda) (1974)
    Springer
    Cell & tissue research 155 (1974), S. 127-134 
    Details
    ISSN: 1432-0878
    Keywords: Organ of Bellonci ; Carcinus maenas (Crustacea, Decapoda) ; Sensory and secretory function ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The organ of Bellonci of Carcinus maenas is made up of onion bodies and secretory cells. The onion body consists of a distal segment, of membranous whorls and granules, and a proximal nuclear cell body. They are joined by a modified double ciliary junction. Both a sensory and secrtory function is suggested. The secretory cells fall into two groups based on size, shape and organelles. Their presence suggests a secretory function to the organ of Bellonci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220289
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The ultrastructure of the sinus gland of Carcinus maenas (Crustacea: Decapoda) (1974)
    Springer
    Cell & tissue research 155 (1974), S. 117-125 
    Details
    ISSN: 1432-0878
    Keywords: Sinus gland ; Carcinus maenas (Crustacea, Decapoda) ; Nerve fibre cell types ; Neurosecretion ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The sinus gland of Carcinus maenas consists of the swollen axonal endings of the neurosecretory cells of the major ganglia and acts as a storage release centre for the membrane bound neurosecretory material. These neurosecretory granules fall into five different types based on size and electron density. Their contents are released by exocytosis of the primary granules or smaller units budded from the primary granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220288
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The effects of lactic acid production on contraction and intracellular pH during hypoxia in cardiac muscle (1993)
    Springer
    Basic research in cardiology 88 (1993), S. 421-429 
    Details
    ISSN: 1435-1803
    Keywords: Cardiac muscle ; hypoxia ; pH ; lactate ; ischaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During hypoxia cardiac contraction declines and there is an intracellular acidosis. We find that, if this acidosis is abolished by decreasing pCO2 there is little restoration of force. Therefore the acidosis is not the major cause of the decline of force. The acidosis may partly result from the generation of lactic acid. No acidosis, is however, seen in isolated cardiac cells. Furthermore a theoretical model shows that lactic acid production would be expected to produce a transient acidosis. We suggest that the observed maintained acidosis may be a consequence of extracellular lactic acid accumulation affecting intracellular pH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00795409
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    Paper (German National Licenses)
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