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  • 1
    Electronic Resource
    Electronic Resource
    Calcium-induced calcium release activates contraction in intact cardiac cells (1989)
    Springer
    Pflügers Archiv 413 (1989), S. 676-678 
    Details
    ISSN: 1432-2013
    Keywords: Cardiac myocyte ; contraction ; sarcoplasmic reticulum ; caged Ca
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The “caged” calcium chelator Nitr-5 was Incorporated into isolated rat ventricular myocytes. Brief illumination with ultra-violet light made the cell twitch. The light-induced twitch was inhibited by ryanodine (1–10 μM) suggesting that it resulted from calcium-induced release of calcium from the sarcoplasmic reticulum. Inhibition of the Ca current (Ni, 10 mM) abolished the electrically stimulated twitch but did not inhibit the light-induced twitch. These results provide direct evidence for the importance of Ca-induced Ca release in excitation-contraction coupling in the heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581820
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Regional differences in the regulation of intracellular sodium and in action potential configuration in rabbit left ventricle (1997)
    Springer
    Pflügers Archiv 433 (1997), S. 515-522 
    Details
    ISSN: 1432-2013
    Keywords: Key words Sodium ; Action potential ; Endocardial ; Epicardial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In this study we report measurements of the intracellular sodium concentration ([Na+]i) in cardiac myocytes isolated from sub-endocardial and sub-epicardial regions of the rabbit left ventricle. These measurements show that [Na+]i is significantly higher in sub-epicardial than in sub-endocardial myocytes both at rest and during steady-state stimulation at 0.5 Hz. During a 10-min rest the rate of fall of [Na+]i was identical in cells from the two regions but during post-rest recovery [Na+]i rose significantly faster in sub-endocardial cells. The effect that this difference in sodium regulation may have on the rate of recovery of the calcium transient post-rest is discussed. The steady-state differences in [Na+]i do not appear to have the effect on contraction we would expect i.e. steady-state contraction is larger in sub-endocardial cells where [Na+]i is lower. Changes in [Na+]i brought about by altering the frequency of stimulation are associated with the expected changes of contraction. Action potentials were found to be significantly longer in sub-endocardial cells and following rest action potential duration was shortened although regional differences were maintained. No regional differences in this effect of rest or in recovery of the action potential post-rest were found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004240050307
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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