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  • 1
    Electronic Resource
    Electronic Resource
    A case of traumatic shock complicated by methamphetamine intoxication (1999)
    Springer
    Intensive care medicine 25 (1999), S. 758-760 
    Details
    ISSN: 1432-1238
    Keywords: Key words Traumatic shock ; Cardiac tamponade ; Metabolic acidosis ; Methamphetamine intoxication ; Hyperammonemia ; Hyperuricemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of a 38-year-old male with traumatic shock complicated by methamphetamine intoxication is presented. The patient was involved in an assault which resulted in cardiac tamponade and right ventricular outflow laceration. Pericardiocentesis was immediately performed. However, profound metabolic acidosis greatly in excess of that expected from the short duration of the shock was revealed by arterial blood gas analysis. Another cause of the metabolic acidosis was suspected. The patient subsequently admitted to intravenous use of methamphetamine. Following hemodynamic and metabolic stabilization by continuous pericardial drainage and intravenous administration of sodium bicarbonate, the patient underwent cardiac surgery. His postoperative course was uneventful. There is a substantial association between methamphetamine users and traumatic accidents. In such cases, early identification of drug use is important. Marked metabolic acidosis, which conflicts with the diagnosed cause of shock, may be a clinical clue to methamphetamine intoxication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050943
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    X-linked mutations that give rise to overproduction of glucose-6-phosphate dehydrogenase in Drosophila melanogaster (1986)
    Springer
    Biochemical genetics 24 (1986), S. 319-327 
    Details
    ISSN: 1573-4927
    Keywords: Drosophila melanogaster ; glucose-6-phosphate dehydrogenase ; X-linked mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Two X-linked mutations that give rise to overproduction of glucose-6-phosphate dehydrogenase (G6PD) were found among the progenies of isogenic strains which had been subjected to selection for high G6PD activity. Mapping of the high-activity factor in these mutants was carried out using car Zw B sw males of low G6PD activity. As a result, the factor mapped 0.02–0.04 unit to the left of the Zw locus. The amount of the G6PD gene was also quantitated utilizing a cloned G6PD gene as a probe, but no significant difference was found between the mutants and low-G6PD activity flies which shared the same X, second, and third chromosomes with the mutants. These findings are consistent with our notion that the mutations might be regulatory mutations, possibly resulting from the insertion of a novel class of transposable genetic elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00502798
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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