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  • 1
    Electronic Resource
    Electronic Resource
    Secondary athrocytotic cardiomyopathy — Heart damage due to Wilson's disease (1980)
    Springer
    Virchows Archiv 387 (1980), S. 67-80 
    Details
    ISSN: 1432-2307
    Keywords: Wilson's disease ; Cardiomyopathy ; Atomic absorption spectrophotometry ; Laser-microprobe-mass-analyzer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Myokard eines 14jährigen Jungen mit Morbus Wilson ergab die postmortale Gewebsmineralanalyse eine ca. 100 fache Erhöhung des Kupfergehaltes. Das Gesamtgewebsionogramm der Herzmuskulatur entsprach in seiner Konstellation einer Myokardose. Die ultrastrukturellen morphologischen Veränderungen waren für eine Kardiomyopathie charakteristisch. Im Laser-Mikrosonden-Massenanalysator LAMMA 500 fand sich eine inhomogene Kupferverteilung. Der Herzmuskelschaden hat offensichtlich eine wesentliche Beteiligung am Todesmechanismus.
    Notes: Summary Post-mortem atomic absorption spectrophotometry of the myocardium of a 14-year-old boy revealed a hundred-fold increase in copper. Further electrolyte analysis of the myocardium showed changes corresponding to metabolic heart muscle damage. Ultrastructural examination showed all the feature of a cardiomyopathy at the cellular level. Laser-Microprobe-Mass-Analysis demonstrated an inhomogeneous distribution of copper. An essential factor in the mechanism of death is heart damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428430
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  • 2
    Electronic Resource
    Electronic Resource
    Morphologic differential diagnosis of idiopathic cardiomyopathies (1977)
    Springer
    Virchows Archiv 374 (1977), S. 71-79 
    Details
    ISSN: 1432-2307
    Keywords: Cardiomyopathy ; Myocardium ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Rasterelektronenmikroskopische Befunde am Herzmuskel bei idiopathischer Kardiomyopathie können eine methodische Bereicherung der Differentialdiagnose dieses seltenen Krankheitsbildes darstellen: Bei zwei FÄllen von kongestiver Kardiomyopathie ist die rÄumliche Architektur der Muskelzellen unverÄndert, bei einem Fall von nicht-obstruktiver hypertrophischer Kardiomyopathie werden sowohl die rÄumlichen Texturstörungen der Herzmuskelzellen als auch der Myofibrillen dargestellt. Die formale Pathogenese der Herzinsuffizienz wird hier mit Hilfe der Rasterelektronenmikroskopie plastisch herausgearbeitet.
    Notes: Summary Scanning electron microscopic examination of the myocardium in cardiomyopathies is a valuable complementary method beside light and transmissionelectron microscopy for the differential diagnosis of this rare disease. In two cases of congestive cardiomyopathy no marked alterations of the myocardial architecture could be found whereas in one case of nonobstructive hypertrophic cardiomyopathy myocardial cell alterations and structure disorders could be demonstrated in an almost stereologic view. The pathogenesis of heart failure in this disease was clearly shown. Similar changes were not observed in hearts without cardiomyopathy or in other forms of cardiac hypertrophy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430571
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Enantioselective high-performance liquid chromatography assay of (+)R- and (-)S-α-lipoic acid in human plasma (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 9 (1997), S. 32-36 
    Details
    ISSN: 0899-0042
    Keywords: chiral thiol derivatisation ; diastereomeric derivative ; reversed phase HPLC ; fluorescence detection ; assay validation ; enantiomer pharmacokinetics ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A specific plasma level assay for the enantiomers of α-lipoic acid is described. It makes use of liquid-liquid extraction, chemical reduction to the dithiol enantiomers, and their precolumn chiral derivatisation with o-phthalaldehyde in the presence of D-phenylalanine. The two diastereomeric derivatives are separated by reversed-phase HPLC with fluorescence detection. The working range of the assay is between 15 ng/ml (lower limit of quantitation) and 1,000 ng/ml for either enantiomer. Chirality 9:32-36, 1997. © 1997 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 4
    Electronic Resource
    Electronic Resource
    Ueber Alkylderivate substituirter Cinchoninsäuren. p-Methoxy-α-phenylcinchoninsäure, p-Oxycinchoninsäure und p-Oxy-α-phenylcinchonin (1894)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 282 (1894), S. 85-107 
    Details
    ISSN: 0075-4617
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.18942820105
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    Paper (German National Licenses)
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