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  • Dopamine  (2)
  • Cardiopulmonary vagal reflex  (1)
  • DOPAC  (1)
  • Excitatory amino acid  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Radioreceptor binding reveals the potencies of N,N-disubstituted 2-aminotetralins as D2 dopamine agonists (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 336 (1987), S. 487-493 
    Details
    ISSN: 1432-1912
    Keywords: 2-Aminotetralins ; N-0434 ; N-0437 ; 3H-Spiperone ; D2 Receptor ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The affinity of a series of N,N-disubstituted 2-aminotetralins for the rat striatal D2 dopamine receptor labelled by [3H]spiperone has been determined. Displacement data for the more potent 2-aminotetralins were better described by a model where the compounds competed for [3H]spiperone at two sites. The high affinity component accounted for approximately 80% of the total sites. Displacement curves for all 2-aminotetralins were shifted to the right by 100 μM guanosine-5′-triphosphate; a result attributable to the redistribution of 13–47% of the sites to a low affinity form. These data are consistent with the N,N-disubstituted 2-aminotetralins being agonists at the D2 dopamine receptor. In particular, the affinities of the 5-hydroxy-2-aminotetralins were as high as those of traditional dopamine agonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169304
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differential effects of IV and IP muscimol on central dopamine metabolism (1981)
    Springer
    Psychopharmacology 74 (1981), S. 71-73 
    Details
    ISSN: 1432-2072
    Keywords: Muscimol ; Dopamine ; DOPAC ; Nigrostriatal ; Mesolimbic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of IV and IP muscimol on the concentrations of dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in both the nigrostriata) and mesolimbic dopaminergic pathways has been studied. IV muscimol (2 mg/kg), produced significant decreases in the concentration of DA in both DA systems, while the concentration of DOPAC remained unaltered. However, IP muscimol (5 and 10 mg/kg) caused significant increases in the concentrations of DA or DOPAC in all brain regions examined. Our results suggest differential actions of muscimol on DA metabolism dependent upon the route of administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431760
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Excitatory amino acid receptors in the caudal ventrolateral medulla mediate a vagal cardiopulmonary reflex in the rat (1989)
    Springer
    Experimental brain research 78 (1989), S. 185-192 
    Details
    ISSN: 1432-1106
    Keywords: Cardiopulmonary vagal reflex ; Bezold-Jarisch reflex ; Excitatory amino acid ; Caudal ventrolateral medulla ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The importance of the caudal ventrolateral medulla (CVLM) in mediating vagal cardiopulmonary (Bezold-Jarisch reflex) reflex activity was studied in urethane-anaesthetized rats. Unilateral electrolytic lesion of the CVLM markedly attenuated Bezold-Jarisch reflex responses (hypotension and bradycardia) elicited by intravenous injections of 5-HT. Bilateral lesion of the CVLM virtually abolished the reflex responses. Microinjection of the excitatory amino acid (EAA) receptor antagonist kynurenate (KYN), but not the inactive analogue xanthurenate, into the CVLM markedly attenuated the reflex responses to 5-HT. The N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 also markedly attenuated reflex activity. Furthermore, lesions, KYN and MK-801 all tended to elevate resting blood pressure and to reduce resting heart rate. These findings support the hypothesis that the CVLM is an important medullary locus mediating cardiovascular reflex integration and that an EAA synapse in the CVLM is important in the cardiopulmonary reflex arc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230698
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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