ISSN:
1432-2013
Keywords:
Carotid Chemoreceptors
;
CO2 Response of Respiration
;
Sinus Nerve Block
;
Vagotomy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In anesthetized rabbits rebreathing oxygen or inhaling constant mixtures of CO2 and O2, the influence of inactivation of the carotid sinus nerves by section or temporary cold blocking on the respiratory response to increased $$P_{A_{{\text{CO}}_{\text{2}} } } $$ was investigated. In some of the experiments the vagi were intact, in others they were cut. Even during respiration of pure oxygen, in part of the animals blocking of the sinus nerves caused a slight diminution of ventilation which was significant only in the vagotomized preparation (average decrease by 11.4%). However, the diminishing effect of the blockade did not increase, but rather decreased, with increasing $$P_{A_{{\text{CO}}_{\text{2}} } } $$ . Similarly, section of the sinus nerves did not cause a significant shift or decrease of slope of the $$P_{A_{{\text{CO}}_{\text{2}} } } $$ response curve. Evidently in the rabbit carotid chemoreceptors do not contribute essentially to the steady-state hyperpnea caused by hypercapnia under hyperoxic conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00592930
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