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  • 1
    Electronic Resource
    Electronic Resource
    Exposure-response relationships between woodworking, smoking or passive smoking, and squamous cell neoplasms of the maxillary sinus (1990)
    Springer
    Cancer causes & control 1 (1990), S. 165-168 
    Details
    ISSN: 1573-7225
    Keywords: Case-control study ; logistic models ; maxillary sinus neoplasms ; occupations ; sinusitis ; tobacco smoke pollution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: A case-control study of squamous cell neoplasms of the maxillary sinus was performed in Hokkaido during 1982–86, with 169 cases and 338 controls matched for sex, age, and residence. The data were analyzed by a stepwise forward-telection method based on a conditional logistic-regression model without interaction terms, log-likelihood ratio tests, and chi-square tests for trend. Statistically significant linear trends were observed for associations between the risk of squamous-cell maxillary-sinus neoplasms and the duration of woodworking among men, the daily or lifetime amount of smoking among men, and the number of smokers in the household as an index of domestic exposure to cigarette smoke among women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00053168
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental rat model representing both acute and chronic heart failure related to autoimmune myocarditis (1995)
    Springer
    Cardiovascular drugs and therapy 9 (1995), S. 701-707 
    Details
    ISSN: 1573-7241
    Keywords: autoimmune myocarditis ; heart failure ; hemodynamics ; dobutamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The most important clinical manifestation of myocarditis is congestive heart failure. The precise mechanisms of heart failure during myocarditis have not been elucidated because no animal model that would permit in vivo study of hemodynamics in severe active myocarditis has been available. We monitored hemodynamics and left ventricular function in a rat model of experimental autoimmune myocarditis to determine if this model could be useful for the study of in vivo hemodynamics in severe active myocarditis. Lewis rats were immunized with human cardiac myosin suspended in complete Freund's adjuvant. Baseline hemodynamics were measured using an ultraminiature catheter pressure transducer via the right internal carotid artery, 4 weeks after immunization in one group of rats (acute phase) and 3 months after immunization in another group (chronic phase). Untreated rats served as the control group. Hemodynamic measurements were also obtained after infusion of dobutamine in the acute-phase and chronic-phase groups. The heart weight-to-body weight ratios were significantly higher in both the acute-phase group and the chronic-phase group compared with normal control rats. The baseline left ventricular systolic pressure was significantly lower in the chronic phase group than in the control group. Peak dP/dt and peak -dP/dt were significantly lower in both the acute-phase group and the chronic-phase group compared with the control group. Dobutamine significantly increased left ventricular systolic pressure, peak dP/dt, and peak -dP/dt in the chronic-phase group but caused only minor changes in hemodynamic variables in the acute-phase group. In vivo measurements of hemodynamic variables indicated the presence of left ventricular dysfunction in rats with experimental autoimmune myocarditis. This animal model may be useful for the study of both acute heart failure related to acute myocarditis and chronic heart failure due to diffuse myocardial fibrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00878553
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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