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6-Hydroxydopamine and the aggressive behavior induced by marihuana in REM sleep-deprived rats (1976)

Musty, Richard E. ; Lindsey, Charles J. ; Carlini, E. A.

Springer

Psychopharmacology 48 (1976), S. 175-179

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ISSN: 1432-2072

Keywords: Aggressiveness ; Marihuana ; 6OH-DA ; Catecholamines ; REM sleep

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract 6-Hydroxydopamine (6OH-DA) pretreatment increased the aggressive behavior induced by marihuana in REM sleep-deprived rats. Brain catecholamine assays revealed that 6OH-DA depleted dopamine (DA) and norepinephrine (NE) to a different extent, increasing the DA/NE ratio. Intraventricular injection of NE significantly decreased the aggressive behavior of these animals, whereas control solution or DA injections had no effect. The possible role played by DA and NE in the aggressive behavior induced by marihuana in REM sleep-deprived rats is discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00423257

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