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  • Catecolamine ¶myotoxicity  (1)
  • Paternity testing  (1)
  • blood pressure  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Myocardial findings in fatal carbon monoxide poisoning: a human and experimental morphometric study (2000)
    Springer
    International journal of legal medicine 113 (2000), S. 276-282 
    Details
    ISSN: 1437-1596
    Keywords: Key words Carbon monoxide poisoning ; Acute ¶toxicity ; Myocardial necrosis ; Catecolamine ¶myotoxicity ; Coagulative myocytolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The aim of this study was to define the status of the myocardium in selected human cases of acute, fatal carbon monoxide intoxication and the myocardial changes in rats exposed to carbon monoxide in relation to the type of cardiac arrest and the effects of reoxygenation following pre-fatal CO intoxication. The human study consisted of 26 cases (17 accidental and 9 suicide) of acute, fatal CO intoxication, without evidence of obstructive coronary atherosclerosis or history of ischemic heart disease which were compared with 45 cases of fatal head trauma in subjects who died instantaneously (26 cases) or within 1–12 h (19 cases). Inhalation of a lethal dose of CO in rats was compared with sub-lethal doses plus reoxygenation with and without pre-treatment by a betablocker. In all human and experimental histological sections, changes were normalised per mm2 area. In the human cases the myocardium did not show any ischemic types of changes or other lesions. Only in “three accidental” cases a few, small foci of coagulative myocytolysis were detected. In the case of spontaneous death in 31 rats following CO intoxication, no pathological myocardial changes were seen. Of the 15 “reoxygenated” rats, 2 of the 7 spontaneous deaths presented coagulative myocytolysis with 15 ± 6 foci and 381 ± 255 necrotic myocells. All the eight rats sacrificed at 3 h had coagulative myocytolysis with 5 ± 4 foci and ¶60 ± 47 myocells. Of the 24 reoxygenated rats pre-treated with a betablocker, 5 died spontaneously after a short survival and 2 of these showed 11 ± 9 foci and 21 ± 20 myocells. The 19 rats sacrificed after 3 h all presented coagulative myocytolysis with figures of 75 ± 43 and ¶356 ± 301 with 0.5 mg/kg of propranolol hydrochloride and 55 ± 45 and 253 ± 216 with 2 mg/kg, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004149900114
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical tolerability of ibopamine hydrochloride (SB 7505) (1981)
    Springer
    European journal of clinical pharmacology 19 (1981), S. 409-411 
    Details
    ISSN: 1432-1041
    Keywords: ibopamine ; hydrochloride ; diuresis ; blood pressure ; side effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The clinical tolerance of ibopamine hydrochloride (SB 7505) was investigated in 12 volunteers. The drug was administered on alternate days (2nd, 4th, 6th, 8th, 10th, 12th), starting at 100 mg and increasing by 50 mg each time to reach 350 mg on the 12th day. On the other days (1st, 3rd, 5th, 7th, 9th, 11th and 13th) a placebo was given. Diuresis increased progressively with the dose, reaching a maximum increase of 88% after the last dose, and showing a small residual effect on each subsequent placebo day. Body weight showed a marginal change and decreased by 2% in the last two days of treatment. Heart rate, systolic, diastolic and mean blood pressure showed only marginal fluctuations of about 7% around the mean values, which were of little statistical and of no clinical significance. Haematological and biochemical parameters were not affected. No side effect was noticed. The dose of 350 mg may probably be increased without leading to side effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548583
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Forensic evaluation of HUMCD4: An Italian database (1996)
    Springer
    International journal of legal medicine 109 (1996), S. 49-51 
    Details
    ISSN: 1437-1596
    Keywords: PCR ; HUMCD4 ; Identification ; Paternity testing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract The YTTTC pentanucleotide short tandem repeat polymorphism HumCD4 was studied in an Italian population sample. PCR products were compared to an allelic ladder by manual PAGE and silver staining. A total of 6 alleles ranging from 5 to 12 repeats were represented in the analysed sample, of which 3 alleles (10, 6 and 5 repeats) were predominant and displayed a combined frequency of 0.91. Successful amplification was obtained from different sources such as blood and urine stains, teeth and paraffin embedded tissues. Results were also determined in cases of severely degraded DNA. We consider that the HUMCD4 polymorphism may be a useful tool for individual identification, paternity testing, population studies and have also employed this locus to monitor engraftment of bone marrow transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01369604
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    Paper (German National Licenses)
    Fulltext
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