ISSN:
1432-069X
Keywords:
Cathepsin H
;
Skin
;
Epidermis
;
Cysteine proteinase
;
Proteinase inhibitors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The rat-skin-derived cysteine proteinase, so-called BANA-hydrolase, which is capable of hydrolysing benzoylarginine naphthylamide and leucine naphthylamide was shown to be immunologically identical to cathepsin H purified from rat liver. The enzyme was immunocytochemically localized in the basal cell layer of rat epidermis. A natural inhibitor of cathepsin H with a molecular weight of about 13,000 was mainly localized in the keratinizing cell layers and showed only a weak reaction in the basal cells. Thus, cathepsin H appears to be a characteristic feature of the proliferating cell layer, whereas the cysteine-proteinase inhibitor is a characteristic feature of keratinizing cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00404315
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