ISSN:
1432-0738
Keywords:
Key words Almitrine bismesylate
;
Detriazinyl
;
metabolite of almitrine
;
Cationic amphiphilic drugs
;
Drug-induced lipidosis
;
Neuropathy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory neurons, satellite cells, Schwann cells, and vascular endothelial cells of the dorsal root ganglia. The lysosomal lamellated bodies, which were not induced by almitrine, were produced also in cultured rat macrophages exposed to over 1×10–5 M DTMA.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002040050189
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