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  • 1
    Electronic Resource
    Electronic Resource
    Does burimamide inhibit gastric acid secretion by a release of catecholamines? (1973)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 279 (1973), S. 417-420 
    Details
    ISSN: 1432-1912
    Keywords: Cats ; Histamine ; Burimamide ; Gastric Acid Secretion ; Gastric Mucosal Blood Flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In anaesthetized cats burimamide inhibits gastric acid secretion, reduces gastric mucosal blood flow, rises blood pressure and increases cardiac frequency. The effects or burimamide on blood pressure, cardiac frequency and on gastric acid secretion are antagonized by reduction of adrenergic influences by adrenalectomy of adrenergic blocking agents. The results indicate that burimamide releases catecholamines which are at least in part responsible for the effects of burimamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500807
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  • 2
    Electronic Resource
    Electronic Resource
    Trennung von Gastrin und Acetylcholin als Reiz für die Säure- und Pepsin-Sekretion bei Katzen (1968)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 259 (1968), S. 419-426 
    Details
    ISSN: 1432-1912
    Keywords: Cats ; Vagus ; Gastrin ; Gastric Secretion ; Katzen ; Gastrin ; Vagus ; Magensekretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die Wirkung des gastrin-analogen Tetrapeptidamids Try.Met.Asp.Phe-NH2 und von elektrischen Vagusreizen auf die Magensekretion von anaesthesierten Katzen mit einer Magenfistel wurde untersucht. 2. Das Tetrapeptid verursachte in Dosen von 0,1–3,2 μg/min i.v. nur eine Sekretion von pepsinarmem Magensaft. 3. Auf elektrischen Vagusreiz wurden große Mengen Magensaft und Pepsin sezerniert. 4. Bei den Katzen mit gekreuztem Kreislauf wurden mit dem Magensaft der gereizten Tiere große Mengen Pepsin ausgeschieden, während der Magensaft der nicht gereizten Tiere nur geringe Mengen Pepsin enthielt. 5. Aus den Versuchen wurde geschlossen, daß durch Vagusreizung Gastrin freigesetzt wird, welches als zirkulierendes Hormon die Säuresekretion stimuliert, und daß die Pepsin-Sekretion durch das bei Vagusreizung freigesetzte Acetylcholin verursacht wird.
    Notes: Summary 1. The effect was studied of the gastrin-analogue tetrapeptide amide Try.Met.Asp.Phe-NH2 and electrical vagus stimulation on gastric secretion in anaesthetized gastric fistula cats. 2. The tetrapeptide in doses of 0.1–3.2 μg/min i.v. stimulated the secretion of gastric juice containing only small amounts of pepsin. 3. Electrical vagus stimulation provoked the secretion of large amounts of gastric juice and pepsin. 4. In pairs of cross circulated cats the gastric juice of the vagus stimulated animals contained much pepsin, the gastric juice of the not stimulated animals did not. 5. It was concluded from these results that gastrin was released by vagal excitation and stimulated as a circulating hormone acid secretion and that pepsin secretion was stimulated by a vagal release of acetylcholine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00538556
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  • 3
    Electronic Resource
    Electronic Resource
    Aufnahme und Verteilung von 14C-l-Glutaminsäure in der Magenschleimhaut von Katzen (1969)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 262 (1969), S. 428-440 
    Details
    ISSN: 1432-1912
    Keywords: Cats ; Gastric mucosa ; 14C-l-Glutamic acid ; Katzen ; Magenschleimhaut ; 14C-l-Glutaminsäure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. An Katzen wurden der Einbau und die Verteilung von 14C-l-Glutaminsäure in der Magenschleimhaut untersucht. 2. Radioaktivität wird 90 min nach der Injektion von 14C-l-Glutaminsäure besonders im Fundus, in geringerer Menge auch im Antrum gegenüber dem Blut angereichert. 18 Std nach der Injektion war ein Verteilungsgleichgewicht zwischen Blut und Antrum- bzw. Fundusschleimhaut vorhanden. 3. Autoradiographisch ließ sich radioaktives Material im Fundus vornehmlich im Bereich der größten Hauptzelldichte nachweisen, während die Belegzellen keine Markierung zeigten. In der Antrumschleimhaut war die Radioaktivität weitgehend gleichmäßig verteilt. 4. 90 min nach der Injektion befand sich der Hauptteil der extrahierbaren Radioaktivität in niedermolekularen, 18 Std nach der Injektion in höhermolekularen Strukturen. 5. In angereicherten Gastrinextrakten der Antrumschleimhaut ließ sich Radioaktivität nachweisen, was den Schluß zuläßt, daß exogen zugeführte 14C-l-Glutaminsäure in endogenes Gastrin eingebaut wird.
    Notes: Summary 1. The incorporation and distribution of 14C-l-glutamic acid in the gastric mucosa was investigated in cats. 2. 90 min after the i.v. injection of 14C-l-glutamic acid, radioactivity was accumulated in larger amounts in the fundic mucosa, than in the antral mucosa of the cat stomach. 18 hours after the injection the radioactivity was equally distributed between blood, antral and fundic mucosa. 3. Autoradiographs demonstrated a localization of radioactivity in the fundus mainly in the area of the chief cells, the parietal cells being unlabelled. In the antral mucosa the radioactivity was equally distributed. 4. Using a gel filtration technique, it was found that 90 min after the injection the bulk of the extractable radioactivity was associated with fractions having a molecular weight lower than that of the fractions with which it was associated 18 hrs after the injection. 5. After the first step of purification (gel filtration) radioactivity was demonstrated in biologically active gastrin fractions suggesting an incorporation of 14C-l-glutamic acid into the gastrin molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00537840
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  • 4
    Electronic Resource
    Electronic Resource
    Acid base balance in relation to gastric acid secretion stimulated by histamine and pentagastrin in cats (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 285 (1974), S. 325-335 
    Details
    ISSN: 1432-1912
    Keywords: Cats ; Gastric Acid Secretion ; Acid Base Balance ; Carbonic Anhydrase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In anaesthetized gastric fistula cats gastric acid secretion and the following blood gases and acid base parameters were determined in the arterial blood and in the gastric venous drainage: pH, HCO 3 − concentration, pCO2 and pO2. 2. During pentagastrin-stimulated gastric acid secretion HCO 3 − concentration and pH rose in the gastric venous effluent and to a small extent in the arterial blood. The venous pO2 dropped. 3. During histamine-stimulated gastric acid secretion, in addition to the changes occurring during pentagastrin-stimulation, an initial drop in arterial pO2, HCO 3 − concentration and pH was observed. 4. After pretreatment of the animals with phenoxybenzamine or mepyramine the effects of histamine in the arterial blood were abolished suggesting that a histamine-mediated release of catecholamines is responsible for these effects of histamine. 5. Inhibition of carbonic anhydrase by acetazolamide inhibited gastric acid secretion and produced a rise in pCO2 with a concomitant drop in pH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501462
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of histamine-H2-receptor-antagonists on gastric acid secretion, gastric mucosal blood flow and acid base balance in cats (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 285 (1974), S. 337-353 
    Details
    ISSN: 1432-1912
    Keywords: Cats ; H2-Receptor-Antagonists ; Gastric Acid Secretion ; Gastric Mucosal Blood Flow ; Acid Base Balance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In anaesthetized acute gastric fistula cats the effect was studied of the histamine-H2-receptor-antagonists burimamide and metiamide on histamine-stimulated gastric acid secretion, gastric mucosal blood flow, and acid base balance of the arterial blood and the gastric venous drainage. 2. Both burimamide and metiamide inhibit gastric secretion and gastric mucosal blood flow. The effects of metiamide are more pronounced than those of burimamide. On acid base balance both histamine-H2-receptor-antagonists have essentially the same effects which reflect the reduced loss of H+ from the stomach. 3. The inhibitory effects of burimamide on the stomach are at least in part antagonized by the histamine-H1-receptor-antagonist mepyramine (which presumably prevents burimamide from releasing catecholamines) and by the α-adrenergic blocking agent phenoxybenzamine, providing indirect evidence for the view that these effects of burimamide are mediated by catecholamines. 4. Phenoxybenzamine and mepyramine do not antagonize the gastric inhibitory effects of metiamide indicating that metiamide is void of catecholamine releasing properties. 5. Phenoxybenzamine and mepyramine influence acid base balance only when the inhibition of gastric acid secretion by burimamide was diminished. They prevented the histamine-mediated drop in arterial pO2, indicating that this histamine effect can be attributed to catecholamines, too.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501463
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  • 6
    Electronic Resource
    Electronic Resource
    Untersuchungen über den Einbau von 14C-l-Glutaminsäure in Pepsin und dessen Ausscheidung in den Magensaft (1969)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 263 (1969), S. 450-461 
    Details
    ISSN: 1432-1912
    Keywords: Cats ; Histamine ; Gastrin-Tetrapeptide ; Vagus Stimulation ; 14C-l-Glutamic Acid ; Gastric Juice ; Pepsin ; Katzen ; Histamin ; Gastrin-Tetrapeptid ; Vagusreizung ; 14C-l-Glutaminsäure ; Magensaft ; Pepsin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. An Katzen wurde die Ausscheidung von Radioaktivität in den Magensaft nach i.v. Injektion von 14C-l-Glutaminsäure unter verschiedenen sekretorischen Reizen untersucht. 2. Radioaktives Material wird in Abhängigkeit vom verwendeten Sekretionsreiz in unterschiedlicher Menge ausgeschieden. 3. Die Menge ausgeschiedener Radioaktivität verlief parallel zur Pepsinausscheidung. 4. Lyophilisierter Magensaft mit hohem Pepsingehalt weist bei der Gelfiltration in den Fraktionen die höchste Radioaktivität auf, die auch am meisten Pepsin enthalten. 5. Aus den Versuchen wird geschlossen, daß 14C-Glutaminsäure in der Magenschleimhaut in Pepsin eingebaut und mit diesem in den Magensaft ausgeschieden wird.
    Notes: Summary 1. The effect of different gastric secretagogues on the secretion of radioactive material into the gastric juice after i.v. injection of 14C-l-glutamic acid was investigated in cats. 2. Radioactive material was secreted into the gastric juice in different quantities depending on the stimulus applied. 3. The amount of radioactivity secreted was in parallel with the secretion of pepsin. 4. Fractionation of freeze dried gastric juice of high pepsin content demonstrated a parallelism between radioactivity and pepsin. 5. It is concluded that 14C-l-glutamic acid is incorporated into the pepsin molecule and is secreted with it into the gastric juice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00538778
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