ISSN:
1432-2072
Keywords:
d-Amphetamine
;
Morphine
;
d-ala2-met-Enkephalin
;
Caudate putamen
;
Behavior
;
Dopamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Bilateral microinjection of morphine (0.003–3 μg/side) into the caudate putamen enhances the behavior induced by the IP injection of 1 mg/kg d-amphetamine phosphate in a dose-related manner. The duration of activity was prolonged and ambulation was changed to d-amphetamine stereotypy, a behavior normally associated with higher doses of d-amphetamine. The opioid activity was stereospecific in that levorphanol was active, whereas dextrorphan was not. The enhancement of d-amphetamine-induced behavior by the opioids was blocked by naloxone. d-ala2-met-Enkephalin also enhanced the amphetamine-induced behavior. This enhancement appears to be specific to the caudate putamen because the oral stereotypy observed appears to be a unique action of amphetamine in this region of the brain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00428204
Permalink