ISSN:
1432-1912
Keywords:
Celiprolol
;
β2-adrenoceptors
;
Mesenteric artery
;
Microcirculation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In order to clarify the question whether the β1-selective adrenoceptor antagonist celiprolol possesses vasodilating properties, isolated vascular networks were perfused with increasing concentrations of celiprolol (in a cumulative manner) ranging from 10−8 to 10−4 mol/l. The study was carried out using the isolated mesenteric vascular bed of the guinea pig mesenterium coli. Vascular diameters of four different vascular regions [vessels classified as G1 (585 ± 30 μm), G2 (403 ± 25 μm), G3 (282 ± 27 μm) and G4 (197 ± 13 μm)] were assessed by means of microscopic videoangiometry. Perfusion with celiprolol resulted in concentration dependent vasodilation which was more pronounced in G3 and G4 vessels. In addition, cumulative concentration-response curves were determined from responses obtained in the presence of 10−8, 10−7, 10−6 and 10−4 mol/l ICI 118,551 (a highly selective adrenoceptor antagonist). In the presence of ICI 118,551 at concentrations ≥ 10−6 mol/l, no celiprolol response could be observed. Lower concentrations of ICI 118,551 shifted the celiprolol concentration-response curve to the right in a concentration-dependent manner. Therefore, it is concluded (a) that celiprolol has a vasodilating effect, (b) that this vasodilation is produced by stimulation of β2-adrenoceptors and (c) that the vasodilating effect is more pronounced in smaller than in larger vessels (G3, G4 vs G1, G2).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00167566
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