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  • 1
    Electronic Resource
    Electronic Resource
    Sexual Violence and Reproductive Health (2000)
    Springer
    Maternal and child health journal 4 (2000), S. 121-124 
    Details
    ISSN: 1573-6628
    Keywords: sexual violence ; sexual assault ; childhood sexual abuse ; rape ; reproductive health ; women's health ; HIV/AIDS ; sexually transmitted disease ; pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sexual violence is a significant public health problem, and has been linked to adverse effects on women's physical and mental health. Although some advances in the research have been made, more scientific exploration is needed to understand the potential association between sexual violence and women's reproductive health, and to identify measures that could be implemented in reproductive health care settings to assist women who have experienced sexual violence. Three general areas needing further study include (1) expansion of the theoretical frameworks and analytic models used in future research, (2) the reproductive health care needs of women who have experienced sexual violence, (3) and intervention strategies that could be implemented most effectively in reproductive health care settings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009574305310
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  • 2
    Electronic Resource
    Electronic Resource
    Pregnancy Intendedness and Physical Abuse Around the Time of Pregnancy: Findings from the Pregnancy Risk Assessment Monitoring System, 1996–1997 (2000)
    Springer
    Maternal and child health journal 4 (2000), S. 85-92 
    Details
    ISSN: 1573-6628
    Keywords: pregnancy ; unintended pregnancy ; unwanted pregnancy ; pregnancy intendedness ; violence ; abuse ; reproductive health ; women's health
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: This study examines whether unintended pregnancy is associated with physical abuse of women occurring around the time of pregnancy, independent of other factors. Methods: In 1996–1997, state-specific population-based data were obtained from the Pregnancy Risk Assessment Monitoring System (PRAMS) from 39,348 women in 14 states who had delivered a live-born infant within the previous 2–6 months. The study questionnaire asked about maternal behaviors and characteristics around the time of pregnancy. Results: Women who had mistimed or unwanted pregnancies reported significantly higher levels of abuse at any time during the 12 months before conception or during pregnancy (12.6% and 15.3%, respectively) compared with those with intended pregnancies (5.3%). Higher rates of abuse were reported by women who were younger, Black, unmarried, less educated, on Medicaid, living in crowded conditions, entering prenatal care late, or smoking during the third trimester. Overall, women with unintended pregnancies had 2.5 times the risk of experiencing physical abuse compared with those whose pregnancies were intended. This association was modified by maternal characteristics; the association was strongest among women who were older, more educated, White, married, not on Medicaid, not living in crowded conditions, receiving first trimester prenatal care, or nonsmoking during the third trimester. Conclusions: Women with unintended pregnancies are at increased risk of physical abuse around the time of pregnancy compared with women whose pregnancies are intended. Prenatal care can provide an important point of contact where women can be screened for violence and referred to services that can assist them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009566103493
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  • 3
    Electronic Resource
    Electronic Resource
    The Pregnancy Risk Assessment Monitoring System (PRAMS): Methods and 1996 Response Rates from 11 States (1999)
    Springer
    Maternal and child health journal 3 (1999), S. 199-209 
    Details
    ISSN: 1573-6628
    Keywords: PRAMS ; surveillance systems ; response rates ; survey methods ; pregnancy ; MCH data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To determine if the Pregnancy Risk Assessment Monitoring System (PRAMS) is a unique and valuable MCH data source and an effective mechanism for states to collect MCH data, and to assess if recent changes in it have improved efficiency and flexibility. Methods: Each component of the PRAMS methodology is described: sampling and stratification, data collection, questionnaire, and data management and weighting. To assess effectiveness, we calculated response rates, contact rates, cooperation rates, refusal rates, and questionnaire completion rates. Logistic regression was used to examine the relationship between maternal and infant characteristics and the likelihood of response. Four criteria were defined to measure improvement in PRAMS functioning. Results: Overall response rates for the 11 states in 1996 ranged from 66% to 80%. Cooperation rates were high (85–99%), with contact rates somewhat lower (73–87%). Response rates were higher for women who were older, White, married, had more education, were first-time mothers, and had a normal-birthweight infant. In all states, parity and education were the most consistent predictors of response, followed by marital status and race. Between 1988–1990 and 1996–1999, the number of states and areas participating in PRAMS increased from 6 to 23, response rates improved, and the time for a state to start data collection and to obtain a weighted dataset both decreased. Conclusions: PRAMS is a unique and valuable MCH data source. The mail/telephone methodology used in PRAMS is an effective means of reaching most women who have recently given birth in the 11 states examined; however, some population subgroups are not reached as well as others. The system has become more efficient and flexible over time and more states now participate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022325421844
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  • 4
    Electronic Resource
    Electronic Resource
    Characteristics of the binding of human C-reactive protein (CRP) to laminin (1989)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 40 (1989), S. 121-132 
    Details
    ISSN: 0730-2312
    Keywords: protein binding ; basement membrane ; PC idiotype ; extracellular matrix glycoproteins ; acute-phase proteins ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Human CRP binds to the basement membrane protein laminin in vitro in a Ca2+-dependent manner via the phosphorylcholine (PC) binding site of C-reactive protein (CRP). The binding was saturable at a molar ratio of 4 (CRP/laminin). The specificity of the binding was shown by inhibition of binding of labeled CRP to laminin by unlabeled CRP, but not by human IgG. Specific binding was optimal in the presence of 5 mM Ca2+, but did not occur in the absence of Ca2+ or in the presence of EDTA. The binding of Ca2+ to CRP causes a conformational change in the molecule, which is required for binding to PC and to laminin. The PC binding site of CRP was implicated in the binding to laminin on the basis of inhibition by both soluble PC and anti-idiotypic mAbs directed to the TEPC-15 PC-binding idiotype found on mouse antibodies to PC. In addition, mouse mAbs specific for the CRP PC binding site displayed decreased reactivity with CRP already bound to laminin. The binding of CRP to laminin provides a possible explanation for selective deposition of CRP at inflamed sites. The CRP-laminin interaction may serve as a means of concentrating CRP at sites of tissue damage so that the CRP might function as a ligand for leukocytes, an event that will result in removal of necrotic tissue and cell debris.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240400112
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  • 5
    Electronic Resource
    Electronic Resource
    Morphologic effects of pressure changes on canine carotid artery endothelium as observed by scanning electron microscopy (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 194 (1979), S. 1-14 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: By using scanning electron microscopy (SEM) we were able to follow the sequence of ultrastructural alterations of the luminal surface which occurred when specimens of canine carotid artery were subjected to controlled transmural pressures. Specimens of carotid artery were removed from dogs following fixation at experimental pressures ranging from 0 mm Hg to 100 mm Hg. The endothelium of specimens fixed at 0 mm Hg has parallel longitudinal ridges formed by the contraction of the underlying internal elastic lamina. With increasing transmural pressure, the luminal surface undergoes a gradual flattening of the endothelial ridges so that at 100 mm Hg, these ridges have completely disappeared. The observed morphologic changes of the arterial endo-thelium indicate that SEM can provide good ultrastructural information on blood vessels subjected to controlled transmural pressure and that the pressure-dependent alterations must be considered in studies on vascular structure and function.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091940102
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  • 6
    Electronic Resource
    Electronic Resource
    Expression of cellular genes in HPV16-immortalized and cigarette smoke condensate-transformed human endocervical cells (1997)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 66 (1997), S. 309-321 
    Details
    ISSN: 0730-2312
    Keywords: oncogenes ; tumor suppressors ; human papillomavirus type 16 ; smoking cofactor ; immortalization ; tumorigenesis ; mRNA ; proteins ; oncogenesis ; senescence ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: We studied the molecular mechanism of successive multistep cervical carcinogenic progression with our previously established in vitro model system. This system was composed of primary human endocervical cells (HEN), two lines of HEN immortalized by HPV16 and their counterparts subsequently malignantly transformed by cigarette smoke condensate (CSC). The expression was examined of diverse cellular genes associated with oncogenesis and senescence, especially for cervical cancer. Consistent results were seen for the pairs of immortalized and malignantly transformed lines. Immortalization of HEN by HPV16 resulted in enhanced expression of H-ras, c-myc, B-myb, p53, p16INK4 and PCNA mRNA; enhanced expression of p16 and PCNA proteins; decreased expression of WAF1/p21/Cip1/Sid1 and fibronectin mRNA; and decreased p53 protein. On the other hand, the CSC-transformed counterparts of HPV16-immortalized cells had up-regulated levels of B-myb, p53 and WAF1 mRNA and p53 protein. Our results indicate that the differential activation or inactivation of multiple cellular genes is important for the immortalization, as well as the transformation, of human cervical cells. Further, we suggest that our in vitro model system is useful for investigating the molecular mechanism of multistep cervical carcinogenesis. J. Cell. Biochem. 66: 309-321, 1997. © 1997 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Laminated cytoplasmic bodies and annulate lamellae in the cat ventrobasal and posterior thalamusSupported by grants NB-06279 and NB-08276 from the National Institutes of Health. (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 167 (1970), S. 183-195 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Large and small laminated cytoplasmic bodies are reported in neurons and dendrites of the ventrobasal and posterior (PO) nuclear groups of the thalamus of the cat. The bodies are more frequently seen in dendritic profiles than in nerve cell bodies. They differ in size, as well as in number and complexity of orientation of the constituent tubules. Their topographic relationship to endoplasmic reticulum, synapses and adhesion plaques is noted and their possible evolution is discussed.A single collection of annulate lamellae is described in the perinuclear soma of one neuron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091670206
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  • 8
    Electronic Resource
    Electronic Resource
    Morphogenesis of the carpal elements in the regenerating forelimb of adult Notophthalmus viridescens viridescensWork supported in part by Grant 011-7124A from The Research Foundation of State University of New York and by Grant RR 05402 (011-EO43C) from USPHS, General Research Support Branch. (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 183 (1975), S. 421-429 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This study is concerned with the morphogenesis of the carpal elements in the regenerating forelimb of the adult newt. Blastema cells surrounding the remnant bony stumps begin to differentiate into cartilage on the twentieth post-amputation day. Subsequently, masses of cartilage build up from the radial and ulnar stumps. The radial mass is larger and differentiates more rapidly than the ulnar mass. By the fifty-fifth post-amputation day, the eight basic carpal elements are formed, with fusion of two of the units, intermedium with ulnare, occurring by the seventieth day. The complexed regenerate possesses the seven carpal elements characteristic of the normal adult limb. The present results show that during limb regeneration in the adult newt the carpal elements are restored to their original number and position and that the pattern of such carpal differentiation proceeds in a proximodistal direction influenced by the stump remnants of the radius and ulna.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091830306
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  • 9
    Electronic Resource
    Electronic Resource
    Isolation of cDNA clones from an osteosarcoma-ROS17/2.8 library by differential hybridization (1994)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 54 (1994), S. 273-280 
    Details
    ISSN: 0730-2312
    Keywords: differential hybridization ; osteoblastic cDNA ; ROS17/2.8 ; chondrocytes ; calvaria ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: We have used differential hybridization to isolate and characterize two novel cDNAs expressed in chondrocytes and some osteoblastic cells. A rat osteosarcoma ROS17/2.8 cDNA library was screened and cDNA clones hybridizing strongly to radiolabeled porcine calvaria cDNA but weakly to a control radiolabeled cDNA were isolated. Two clones were obtained - p.6.1 and p.10.15. A radiolabeled probe of p10.15 was shown to hybridize specifically to a 2.3 Kb message RNA from a chondrogenic clonal cell population from rat calvaria-RCJ 3.1C5.18, and the mRNA was downregulated by 1,25 (OH)2D3, which inhibits chondrogenesis in these cells. The other clone, p6.1, was found to hybridize to a 0.95 Kb message that is expressed in rat liver, kidney, lung, muscle, and brain, but not expressed in spleen and expressed only in low levels in thymus.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240540303
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  • 10
    Electronic Resource
    Electronic Resource
    Incorporation of [3H]inositol into phosphoinositides and inositol phosphates by rabbit blastocysts (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 34 (1993), S. 391-395 
    Details
    ISSN: 1040-452X
    Keywords: Inositol 1,4,5-trisphosphate ; Phosphatidylinositol ; Rabbit embryo ; Cell function ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Preimplantation rabbit embryos collected at the early morula stage were cultured to blastocysts in the presence of [3H]inositol. The blastocysts were lysed, and both the aqueous and lipid portions were analysed for incorporated radioactivity. Thin-layer chromatographic separation of the lipid portion indicated that [3H]inositol was incorporated into phosphatidylinositol, phosphatidylinositol 4-phosphate, and phosphatidylinositol 4,5-bisphosphate. HPLC anion-exchange chromatography indicated that [3H]inositol was incorporated into inositol phosphates, including the two second messengers, inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate, and also inositol monophosphate and inositol 1,4-bisphosphate. These results provide evidence that rabbit blastocysts may have an active phosphatidylinositol second messenger system, which may be responsive to intrauterine factors or intraembryonic paracrine factors. © 1993 Wiley-Liss, Inc.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080340407
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